Abstract: Objective: To investigate the differences of serological profiles in primary Sjogren’s Syndrome (pSS) and evaluate their correlation with the clinical characteristics of parotid glands. Methods: The retrospective study included 289 patients who fulfilled the diagnosis for pSS adviced by American-European Consensus Group Criteria in 2002. The patients were categorized by the clinical features of parotid glands: group1 (massive group), group 2 (infection group), group 3 (swelling group) and group 4 (others). The demographic data and serological profiles among these groups were compared. Statistical analyses of the results between groups were performed using the Student t test, Fisher's exact test, chi-square and analysis of variance. Results: There was differences of serological profiles in accordance with the different clinical characteristics of parotid glands of pSS patients. Serum IgG value in Group 1 was the greatest, and complement C4 was lowest in four groups. Serum IgE value in Group 2 was the greatest and ESR in Group 3 was the greatest among the four groups. Conclusion: This study demonstrates the differences of serological profile in different clinical features of parotid glands of pSS patients, which may be benefit to advance our understanding of the disease.

Key words: [Keywords] , primary Sjogren’s syndrome, serological profiles, parotid gland

摘要： 目的：研究不同腮腺症状的原发性舍格伦综合征（ primary Sj?觟gren’s syndrome，pSS）患者之间的血清学特征的差异性。方法：回顾性研究289名患者，均符合原发性舍格伦综合征（2002年修订的欧美联合诊断标准）。依据患者腮腺的临床特征，将患者分为以下4组：第1组（类肿瘤组）、第2组（感染组）、第3组（肿大组）、第4组（口干组）。对比各组之间的人口统计学和血清学特征。每两组之间结果的统计学分析用t检验，F检验，卡方检验，方差分析。结果：不同的腮腺临床特征的pSS患者具有不同的血清学表型。第1组的血清免疫球蛋白IgG值是4组中最高的，而补体C4是4组中最低的。第2组的血清免疫球蛋白IgE值是4组中最高的。第3组的血沉值是4组中最高的。结论：不同腮腺临床症状的pSS患者具有不同的血清学表型。这可能有助于增进我们对该疾病的认识。

关键词: 原发性舍格伦综合征；  , 血清学表型；  , 腮腺

CLC Number: 

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• R781.77