《Journal of Oral and Maxillofacial Surgery》 ›› 2017, Vol. 27 ›› Issue (4): 234-240. doi: 10.3969/j.issn.1005-4979.2017.04.002

• Basic Scientific Study • Previous Articles     Next Articles

Dopamine Transportor Hypoexpression Influences the Taste-to-nutrition Suitability

 XIAO  Fan-1, HAN  Wen-Fei-1, MENG  Bo-2, JIAN  Sheng-1   

  1. 1. Department of Prothodontics, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Regeneration, Shanghai 200072; 2. Key Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai 200062, China
  • Received:2017-03-28 Revised:2017-06-11 Online:2017-06-08 Published:2018-06-29

多巴胺转运体减少对于味觉偏好转化的影响

 肖凡1, 韩雯斐1, 孟博2, 苏俭生1   

  1. 1. 上海牙组织修复与再生工程技术研究中心,同济大学口腔医学院·同济大学附属口腔医院口腔修复教研室,上海200072; 2. 华东师范大学脑功能基因组学教育部重点实验室,上海市脑功能基因组学重点实验室,上海   200062
  • 通讯作者: 苏俭生,教授. E-mail:E-mail: sjs@tongji.edu.cn
  • 作者简介:肖凡(1990—),女,山东人,硕士研究生. E-mail: shawfan@126.com
  • 基金资助:

    国家自然科学基金(81371949);国家自然科学基金(81572114);国家自然科学基金(81671014)

Abstract: Object: To analyze the influence of DAT (dopamine transporter) hypoexpression in the taste-to-nutrition suitability. Method: 20 DATIREScre heterozygous and littermates wild type controls were tested with series of taste behavior assays, also western blot was applied to measure the DAT expression in different brain regions. Results: Compared with the littermate control, heterozygous mice showed normal taste and nutrition sensation and preference; however, they expressed abnormalities when the taste and post-ingestive nutrition were mismatched. Conclusion: Dopamine information is necessary for coding nutrition valances. DAT hypoexpression interferes the nutritional sensing. This may be the potential mechanism of anorexia in the attention deficit hyperactivity disorder.

Key words:  dopamine transport(DAT), taste-to-nutrition suitability, nutritional sensibility, attention deficit hyperactivity disorder(ADHD)

摘要: 目的:通过建立小鼠味觉转化模型,研究多巴胺转运体(dopamine transporter, DAT)对这一行为的作用。方法:使用20只DATIRES CRE +/-的杂合小鼠和20只DATIREScre-/-的对照小鼠进行一系列味觉相关的行为学测试,通过Western Blot检测小鼠体内DAT蛋白在不同脑区的表达情况。结果:DATIREScre杂合组和对照组相比,其先天性味觉选择以及营养感受与分辨没有异常,但是在味觉感受转化时,尤其是在厌恶性味觉向偏好性味觉的转化中出现异常。结论:消化后营养感受需要多巴胺系统参与,多巴胺转运体表达降低会干扰这一重要过程。这可能是临床上注意力缺失过动症儿童挑食症状的潜在机制。

关键词: 多巴胺转运体 ,  味觉偏好转化 ,  营养感受 ,  注意力缺失过动症

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