Regeneration of tooth and maxillofacial bone defects based on stem cell aggregates

doi:10.12439/kqhm.1005-4979.2023.05.001

《Journal of Oral and Maxillofacial Surgery》 ›› 2023, Vol. 33 ›› Issue (5): 277-284. doi: 10.12439/kqhm.1005-4979.2023.05.001

• Critical Review • Next Articles

Regeneration of tooth and maxillofacial bone defects based on stem cell aggregates

FU Fei¹^,²(), HU Jiachen¹, SUI Bingdong¹, XUAN Kun¹^,², JIN Yan¹()

¹ State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Department of Oral Histopathology, the Third Affliated Hospital of Air Force Medical University, Xi'an 710032
² State Key Laboratoy of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, the Third Affliated Hospital of Air Force Medical University, Xi'an 710032, China

Received:2023-09-06 Accepted:2023-09-15 Online:2023-10-28 Published:2023-11-03

干细胞聚合体在牙颌组织缺损再生修复中的应用

付菲¹^,²(), 胡佳辰¹, 隋秉东¹, 轩昆¹^,², 金岩¹()

¹ 口颌系统重建与再生全国重点实验室，国家口腔疾病临床医学研究中心，陕西省口腔疾病国际联合研究中心，空军军医大学第三附属医院口腔组织病理学教研室，西安　710032
² 口颌系统重建与再生全国重点实验室，国家口腔疾病临床医学研究中心，陕西省口腔疾病临床医学研究中心，空军军医大学第三附属医院预防科，西安　710032

通讯作者: 金岩，教授. E-mail: yanjin@fmmu.edu.cn

作者简介:

付菲，硕士研究生. E-mail: fufeifmmu@163.com

[专家介绍]金岩，空军军医大学口腔医院主任医师、教授、博士生导师，第四军医大学组织工程研发中心创始人、教育部“长江学者”特聘教授、国家杰出青年基金获得者、教育部“创新团队”牵头人。曾担任中国组织工程与再生医学分会第二任主任委员、中华口腔医学会口腔生物医学分会第二任主任委员。获选2015年中国科学年度新闻人物、2016年全国优秀科技工作者，获得2019年中国组织工程与再生医学杰出贡献奖、2020年中国口腔生物医学杰出贡献奖。金岩教授长期从事干细胞、细胞外囊泡、组织工程与再生医学研究，是国家重大基础研究发展计划（973计划）项目及国家重点研发计划项目首席科学家。金岩教授成功研制出我国第一个组织工程产品——组织工程皮肤和世界上第一个生物工程角膜产品；在国际上首次实现了基于干细胞的临床全牙髓再生和牙髓-牙周联合再生，建立了牙髓病和脱位牙的临床治疗新技术；制备和应用了工程化细胞外囊泡；两次获得中国医药生物技术十大进展；以通信作者在Cell Metabolism、Nature Biomedical Engineering、Science Translational Medicine等杂志发表论文200余篇，主编专著6部；获国家科技进步一等奖1项、省部级科技一等奖5项。

基金资助:
国家自然科学基金(81930025); 国家自然科学基金(82071075)

Abstract

Abstract:

Dental and maxillofacial tissue defects represented by tooth defect and/or loss, and maxillofacial bone defect are very common in oral and maxillofacial patients. The current treatment methods include autologous or allogeneic tissue transplantation, artificial synthetic material simulation replacement, etc., which cannot achieve physiological dental and maxillofacial tissue structure and function repair. Mesenchymal stem cells (MSCs) have extensive and powerful potential in regenerative medicine application. Stem cell polymer technology based on the principle of mesenchymal condensation and development has the functional characteristics of maintaining cell stemness, remodeling regenerative microenvironment, and restarting histological differentiation. It has been successfully applied to the regeneration and repair of dental pulp, periodontal and bone tissue, which has obtained good efficacy in related clinical trials, and possess a better clinical transformation prospect. Good results have been obtained in relevant clinical trials, and it has a good prospect of clinical transformation. This review highlights the theoretical basis, construction method and research status of stem cell polymerization in dental tissue regeneration, so as to provide new clinical treatment ideas for better realization of the regeneration and repair of dental tissue defects.

Key words: mesenchymal stem cells, stem cell aggregates, defect restoration, tooth regeneration, bone regeneration

摘要：

以牙缺损、缺失和颌面部骨组织缺损等为代表的牙颌组织缺损在口腔颌面部疾病中十分常见，目前的治疗方式包括自体或同种异体组织移植、人工合成材料的仿真替代等，不能实现生理性的牙颌组织结构和功能的修复。间充质干细胞（mesenchymal stem cells，MSCs）具有广泛而强大的再生医学应用潜能，基于间充质凝聚发育原理的干细胞聚合体技术，其具有维持细胞干性、重塑再生微环境和重启组织分化的功能特性，已经成功应用于牙髓、牙周、骨组织的再生修复，并在相关临床试验中取得良好效果，具有较好的临床转化前景。本文将从干细胞聚合体的制备原理、构建方式和转化应用等方面进行探讨，以期为更好实现牙颌组织缺损的再生修复提供新的理论依据和治疗策略。

关键词: 间充质干细胞, 干细胞聚合体, 缺损修复, 牙再生, 骨再生

CLC Number:

R782

FU Fei, HU Jiachen, SUI Bingdong, XUAN Kun, JIN Yan. Regeneration of tooth and maxillofacial bone defects based on stem cell aggregates[J]. 《Journal of Oral and Maxillofacial Surgery》, 2023, 33(5): 277-284.

付菲, 胡佳辰, 隋秉东, 轩昆, 金岩. 干细胞聚合体在牙颌组织缺损再生修复中的应用[J]. 《口腔颌面外科杂志》, 2023, 33(5): 277-284.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2023.05.001

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