Recent Advances of Graphene Bulk Materials Applications in Oral Regenerative Medicine

doi:10.3969/j.issn.1005-4979.2017.05.012

Abstract

Abstract:

Graphene bulk materials can optimally imitate the physical, chemical and biological properties of the extracellular matrix, promoting the adhesion, growth and specific differentiation of stem cells. The interaction of graphene materials to stem cells can lead the cells differentiate into osteoblasts. Thus, graphene bulk materials may have the potentialls for oral tissue and bone regenerative medicine in oromaxillo-facial region.

Key words:

graphene, scaffold, bone regeneration, nerve regeneration, heart regeneration

摘要：

石墨烯块体材料能最佳模仿细胞外基质的理化特性和生物学性能，促使干细胞粘附、生长和定向分化。干细胞能和石墨烯相互作用，并向成骨细胞、神经细胞和心肌细胞等方向分化，具有口腔组织、骨组织、神经和心脏的再生潜能。

关键词: 石墨烯, 支架材料, 骨再生, 神经再生, 心脏再生

CLC Number:

R782

LU Jia-yu, GUO Xiao-jing, SHAO Zheng-wei, HE Yu-shi, ZOU De-rong.

Recent Advances of Graphene Bulk Materials Applications in Oral Regenerative Medicine

[J]. 《Journal of Oral and Maxillofacial Surgery》, doi: 10.3969/j.issn.1005-4979.2017.05.012.

陆家瑜,郭晓静,邵正威,何雨石（综述）,邹德荣（审校）. 石墨烯块体材料在再生医学中的应用[J]. 《口腔颌面外科杂志》, doi: 10.3969/j.issn.1005-4979.2017.05.012.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2017.05.012

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2017/V27/I5/362

References

[1] Pumera M. Graphene in biosensing[J]. Mater Today, 2011, 14(7):308-315.

[2] Meyer JC, Kisielowski C, Erni R, et al. Direct imaging of lattice atoms and topological defects in graphene membrane[J]. Nano Lett, 2008, 8(11):3582-3586.

[3] Liu Z, Robinson JT, Tabakman SM, et al. Carbon material for drug delivery & cancer therapy[J]. Mater Today, 2011, 14(7):316-323.

[4] Zhang W, Guo ZY, Huang DQ, et al. Synergistic effect of chemo-photothermal therapy using PEGylated grapheme oxide[J]. Biomaterials, 2011, 32(33):8555-8561.

[5] Hu WB, Peng C, Luo WJ, et al. Graphene-based antibacterial paper[J]. ACS Nano, 2010, 4(7):4317-4323.

[6] Zhang Y, Nayak TR, Hong H, et al. Graphene: a versatile nanoplatform for biomedical applications[J]. Nanoscale, 2012, 4(13):3833-3842.

[7] Ma Y, Zhao MG, Cai B, et al. 3D graphene foams decorated by CuO nanoflowers for ultrasensitive ascrobaic acid detection [J]. Biosens Bioelectron, 2014, 59(9):384-388.

[8] Xu Z and, Gao C. Graphene chiral liquid crystals and macroscopic assembled fibres[J]. Nat Commun, 2011, 2(6):1145-1154.

[9] Lu JY, He YS, Cheng C, et al. Self-supporting graphene hydrogel film as an experimental platform to evaluate the potential of graphene for bone regeneration[J]. Adv Funct Mater, 2013, 23(28):3494-3502.

[10] Qiu L, Liu JZ, Chang SLY, et al. Biomimetic superelastic graphene-based cellular monoliths[J]. Nat Commun, 2012, 3(4):187-190.

[11] Jiang LL and Fan ZJ. Design of advanced porous graphene materials: from graphene nanomesh to 3D architectures [J].Nanoscale, 2014, 6(4):1922-1945.

[12] Lee TJ, Park S, Bhang SH, et al. Graphene enhances the cardiomyogenic differentiation of human embryonic stem cells[J]. Biochem Biophys Res Commun Biochem Bioph Res Co, 2014, 452:174-180, 2014, 452(1):174-180.

[13] Dalby MJ, Gadegaard N, Tare R, et al. The control of human mesenchymal cell differentiation using nanoscale symmertry and disorder[J]. Nat Mater, 20078, 6(12):997-1003.

[14] Lu J, Cheng C, He YS, et al. Multilayered graphene hydrogel membranes for guided bone regeneration [J]. Adv Mater, 2016, 28(21):4025-4031.

[15] Stevens MM.Biomaterials for bone tissue engineering[J]. MaterToday, 2008, 11(5):18-25.

[16] Xie H, Cao T, Gomes JV. Two and three-dimensional graphene substrates to magnify osteogenic differentiation of periodontal ligament stem cells[J]. Carbon, 2015, 93:266-275.

[17] Mar VS, Salvador AC, Eva J.Silk-fibroin and graphene oxide composites promote human periodontal ligament stem cell spontaneous differentiation into osteo/cementoblast-like cells.Stem Cells and Development, 2016, 25(22): 1742-1754.

[18] Lim HN, Huang NM, Lim SS, et al. Fabrication and characterization of graphene hydrogel via hydrothermal approach as a scaffold for preliminary study of cell growth[J].Int J Nanomed, 2011, 6(1):1817-1823.

[19] Crowder SW, Prasai D, Rath R, et al. Three-dimensional graphene foams promote osteogenic differentiation of human mesenchymal stem cells[J]. Nanoscale, 2012, 5(10):4171-4176.

[20] Wan C, Frydych M, Chen BQ. Strong and bioactive gelatin-graphene oxide nanocomposites[J]. Soft Matter, 2011, 7(13):6159-6166.

[21] Dinescu S, Ionita M, Pandele A M, et al. In vitro cytocompatibility evaluation of chitosan/graphene oxide 3D scaffold composites designed for bone tissue engineering [J]. Biomed Mater Eng, 2014, 24(6):2249-2256.

[21] Kumar S, Azam MD, Raj S, et al. 3D scaffold alters cellular response to graphene in a polymer composite for orthopedic applications[J]. J Biomed Mater Res B Appl Biomater, 20156, 104(4):732-749.

[22] Lee YK, Bae JW, Hoang Thi TT, et al. Injectable and mechanically robust 4-arm PPO-PEO/graphene oxide composite hydrogels for biomedical applications[J]. Chem Commun (Camb), 2015, 51(42):8876-8879.

[24] Ruan J, Wang XS, Yu Z, et al. Enhanced physiochemical and mechanical performance of chitosan-grafted graphene oxide for superior osteoinductivity[J]. Adv Func. Mater, 2015, 26(7):1085-1097.

[25] Wang JK, Xiong GM, Zhu MM, et al. Polymer-enriched 3D graphene foams for biomedical applications[J]. ACS Appl Mater Interfaces, 2015, 7(15):80-83.

[26] Li N, Zhang Q, Gao S, et al. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells[J]. Sci Rep, 2013, 3(4):132-132.

[27] Shah S, Yin, PT, Uehara TM, et al. Guiding stem cell differentiation into oligodendrocytes using graphene-nanofiber hybrid scaffolds [J]. Adv Mater, 2014, 26(22):25-32.

[28] Hou CY, Duan YR, Zhang QH, et al. Bio-applicable and electroactive near-infrared laser-triggered self-healing hydrogels based on graphene networks[J]. J Mater Chem, 2012, 22(30):14991-14996.

[29] Kim TH, Lee KB, Choi JW. 3D graphene oxide-encapsulated gold nanoparticles to detect neural stem cell differentiation[J]. Biomaterials, 2013, 34(34):8660-8670.

[30] Serrano MC, Patino J, Garcia-Rama C, et al. 3D free-standing porous scaffolds made of graphene oxide as substrates for neural cell growth[J]. J Mater Chen B, 2014, 2(34):5698-5706.

[30] Jakun AE, Secor EB, Rutz AL, et al. Three-dimensional printing of high-content graphene scaffolds for electronic and biomedical application[J]. ACS Nano, 2015, 9(4):4636-4648.

[31] Han J, Park J, Kim BS, et al.Integration of mesenchymal stem cells with nanobiomaterials for the repair of myocardial infarction[J]. Adv Drug Deliver Re., 2015, 95(19):2163-2166.

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