Abstract: Objective: This study was aimed to evaluate the regenerative potential of concentrate growth factors(CGF) complex with bone substitute material in osteoinduction. Method: Twelve health hybrid dogs were used. Bilateral first mandibular premolars were extracted and BLB implants were installed immediately into the sockets. Bone defect (measured 2mm ×4mm) was created in the distal aspect of each socket. Bone defect in both sides of the mandible were randomly divided into experiment or control groups. In experimental group, bone defects were filled with CGF complex and bone substitute material, in control group only bone substitute material were used. Every 4 dogs were killed  at the end of 4、8 and 12 weeks respectively. Specimens were obtained and checked by X ray examination, scanning electric microscope observation, histological examination and survey the bone contact ratio(BCR）. SPSS 11.5 was used. Results were statistically analyzed via one-way analysis of variance (ANOVA), with a significance level of P<0.05. Results: The experimental group manifested osseointegration process earlier  than the control group,  the healing time of bone defect is also earlier than the control group. The BCR of experimental group was also higher than control group. Conclusion: CGF has the ability of promote the peri-implant bone regeneration, facilitate the osseointegration between implant and bone, and at the same time shorten the time needed for the process.

Key words:  concentrate growth factors, immediate implant, bone defect, osseointegration, dog

摘要： 目的：浓缩生长因子（concentrate growth factors, CGF）联合骨代用品（羟基磷灰石生物陶瓷）与单纯应用羟基磷灰石生物陶瓷进行对比，探讨两者在口腔即刻种植中对种植体周围骨缺损修复再生的影响。方法：选择12只健康杂种犬，拔除双侧下颌骨第一前磨牙,随机选取实验组和对照组，并行即刻种植术，植入BLB种植体，实验组加入CGF和羟基磷灰石生物陶瓷的混合物，对照组只加入羟基磷灰石生物陶瓷。于术后4、8、12周分别处死4只动物后取得标本，进行X线、扫描电镜、组织学观察，并进行骨结合率(bone contact ratio，BCR)的测量。结果：术后4、8、12周，通过大体观察、X线观察、组织学观察及扫描电镜观察，实验组比对照组在更早的时间内达到了骨结合，骨缺损区的愈合时间也较对照组早，且实验组BCR值也高于对照组，并有显著差异。结论：CGF具有促进新骨形成和种植体骨结合的能力，并缩短了这一过程所需的时间。

关键词: 浓缩生长因子, 即刻种植, 骨缺损, 骨结合, 犬

CLC Number: 

• R782.13