Role of Yap/Taz in alveolar bone remodeling after unloading of occlusal force

doi:10.12439/kqhm.1005-4979.2026.01.002

Abstract

Key words: unloading of occlusal force, alveolar bone remodeling, mesenchymal stem cells, Yap/Taz, osteogenic differentiation

关键词: 咬合力缺失, 牙槽骨骨改建, 间充质干细胞, Yap/Taz, 成骨分化

ZHANG Hao, WANG Zuolin. Role of Yap/Taz in alveolar bone remodeling after unloading of occlusal force[J]. 《Journal of Oral and Maxillofacial Surgery》, 2026, 36(1): 11-18.

张昊, 王佐林. Yap/Taz在咬合力缺失后牙槽骨骨改建中的作用研究[J]. 《口腔颌面外科杂志》, 2026, 36(1): 11-18.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2026.01.002

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2026/V36/I1/11

Figures/Tables 6

Table 1 Primer sequences used for RT-qPCR

基因名称	正向引物序列（5'-3'）	反向引物序列（5'-3'）
β-actin	GGCTGTATTCCCCTCCATCG	CCAGTTGGTAACAATGCCATGT
CD105	CCCTCTGCCCATTACCCTG	GTAAACGTCACCTCACCCCTT
Yap	ACCCTCGTTTTGCCATGAAC	TGTGCTGGGATTGATATTCCGTA
Taz	CATGGCGGAAAAAGATCCTCC	GTCGGTCACGTCATAGGACTG
Runx2	CCCAGCCACCTTTACCTACA	TATGGAGTGCTGCTGGTCTG
Sp7	GGCGTCCTCTCTGCTTGAG	TTCCCCAGGGTTGTTGAGTC
Col1a1	CCTGGAATGAAGGGACACCG	CCATCGTTACCGCGAGCACC
Bglap	GAACAGACAAGTCCCACACAGC	TCAGCAGAGTGAGCAGAAAGAT

Figure 1 Significant bone loss of mandibular alveolar bone in mice after unloading of occlusal force

Figure 2 Number of MSCs (CD105⁺ cells) in alveolar bone decreased significantly after unloading of occlusal force

Figure 3 Identification of mouse alveolar bone-derived MSCs

Figure 4 The expression levels of Yap/Taz in alveolar bone decreased significantly after unloading of occlusal force

Figure 5 Knocking down Yap/Taz weakens the osteogenic differentiation ability of alveolar bone-derived MSCs

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