炎症微环境中破骨细胞分化及其功能特点的研究进展

doi:10.12439/kqhm.1005-4979.2026.02.009

《口腔颌面外科杂志》 ›› 2026, Vol. 36 ›› Issue (2): 139-142. doi: 10.12439/kqhm.1005-4979.2026.02.009

炎症微环境中破骨细胞分化及其功能特点的研究进展

王琎¹(), 王雅冰², 苏俭生¹()

¹ 上海市同济口腔医院口腔修复科，同济大学口腔医学院，上海牙组织修复与再生工程技术研究中心，同济大学口腔医学研究所，上海　200072
² 牙体牙髓科，上海　200072

收稿日期:2024-12-05 接受日期:2025-01-20 出版日期:2026-04-28 上线日期:2026-04-28
通讯作者: 苏俭生，教授． E-mail: sjs@tongji.edu.cn
作者简介:
王琎，博士研究生. E-mail: jinw99@tongji.edu.cn
基金资助:
国家自然科学基金(82201077)

Research progress in the differentiation and function of osteoclasts in the inflammatory microenvironment

WANG Jin¹(), WANG Yabing², SU Jiansheng¹()

¹ Department of Prosthodontics, Shanghai 200072, China
² Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Endodontics, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, China

Received:2024-12-05 Accepted:2025-01-20 Published:2026-04-28 Online:2026-04-28

摘要/Abstract

摘要：

破骨细胞是骨吸收细胞，其在生理性骨重塑及病理性骨吸收中均发挥重要作用。炎症是导致病理性骨吸收的一大诱因。研究发现，炎症微环境下分化出的破骨细胞起源于特殊标记的前体细胞，其相较于生理状态下的破骨细胞，具有更高的骨吸收能力。此外，其还可通过与其他免疫细胞、基质细胞的相互作用进一步调控骨破坏进程，是研究炎症性骨吸收机制及治疗方法的重要切入点。本文旨在对炎症微环境中破骨细胞的分化与功能特点作一综述。

关键词: 炎症, 破骨细胞, 骨吸收

Abstract:

Osteoclasts are bone-resorbing cells that play essential roles in both physiological bone remodeling and pathological bone resorption. Inflammation serves as a significant inducer of pathological bone resorption. Studies have shown that osteoclasts differentiated in the inflammatory microenvironment originate from specific marked osteoclast precursors and also exhibit enhanced bone-resorbing capacity compared with those under physiological conditions. Moreover, these inflammation-derived osteoclasts further regulate bone destruction processes through crosstalk with stromal and immune cells. Therefore, osteoclasts in the inflammatory microenvironment are crucial for understanding the pathogenesis of inflammatory bone loss and developing targeted therapeutic strategies. This article reviews the differentiation mechanisms and functional properties of osteoclasts in the inflammatory microenvironment.

Key words: inflammation, osteoclasts, bone resorption

中图分类号:

王琎, 王雅冰, 苏俭生. 炎症微环境中破骨细胞分化及其功能特点的研究进展[J]. 《口腔颌面外科杂志》, 2026, 36(2): 139-142.

WANG Jin, WANG Yabing, SU Jiansheng. Research progress in the differentiation and function of osteoclasts in the inflammatory microenvironment[J]. 《Journal of Oral and Maxillofacial Surgery》, 2026, 36(2): 139-142.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2026/V36/I2/139

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