摘要： 目的： 探讨富血小板血浆复合珊瑚羟基磷灰石，修复即刻种植时种植体周围骨缺损的效果。方法： 8只实验用犬，拔除双侧下颌第2、3、4前磨牙，每个拔牙窝即刻植入1枚种植体，并制备种植体颈部的半环状骨缺损。将同一实验犬的6处种植体周骨缺损随机分为3组给予不同方法处理，每组2处。具体如下：A组骨缺损中植入珊瑚羟基磷灰石-富血小板血浆复合物，B组骨缺损中单纯植入珊瑚羟基磷灰石，C组中骨缺损空置。术后3个月处死动物，制作标本，分别进行大体观察，生物力学测试，组织形态学观察、测试（骨结合率）。结果： 骨结合率、生物力学结果一致，均为A组最佳，B组次之，C组最差，且3组间差异有统计学意义(P<0.05)。结论： 富血小板血浆复合珊瑚羟基磷灰石可促进即刻种植时种植体周围的骨生成，提高骨结合率。

关键词: 富血小板血浆, 即刻种植, 骨结合, 珊瑚羟基磷灰石

Abstract: Objective: The purpose of the present study was to examine the bone-inductive activity of  platelet-rich plasma (PRP) and coralline hydroxyapatite (CHA) compound for bone regeneration in immediate implants. Methods: 8 beagle dogs were used. Under general anesthesia, 2,3 and 4 premolars in both sides of the mandible were extracted and immediate implants were placed. In vivo circumferential defects  were created around the neck of implant and filled with PRP + CHA (group A), CHA (group B) or left unfilled (group C). Dogs were sacrificed at the end of 3-month after surgery. The specimens were examined by gross examination, histological observation and biomechanics. Result: Percentage of bone-implant contacts (BIC) was found the best in group A, group B was followed by, group C was the worst. Importantly, there was significant difference between these 3 groups (P<0.05). In addition, biomechanics test was detected in a similar result with BIC. Conclusion:  These findings demonstrate that PRP + CHA compound  is more effective in bone formation  during the repair of bone defects in immediate implant, which indicating that it may be useful in the treatment of various bone defects.

Key words: platelet-rich plasma, immediate implant, osseointegration, coralline hydroxyapatite

中图分类号: 

• R782.2