摘要： 目的：探讨口腔组织（如牙龈、舌、下唇和唇腺）活检，对诊断淀粉样变性的临床意义。方法：对2010-05-2012-04期间，38例疑诊为淀粉样变性的病例行口腔组织活检。其中牙龈活检30例（含同时行唇腺活检2例），舌活检7例，下唇活检1例。所有活检标本送病理科，行HE染色和刚果红特染。结果：经口腔组织活检确定淀粉样变性阳性标本13例。在阳性病例中，活检部位牙龈6例、舌5例、下唇组织1例、唇腺1例。阳性的淀粉样变性病理诊断可提供淀粉样变性确诊依据。在25例阴性病例中，仍有2例通过腹壁脂肪活检、1例经前臂脂肪活检和1例经肾活检电镜观察后，其淀粉样变性诊断得以确定。结论：口腔组织活检具有易于取材、创伤小、恢复快的优点，可作为淀粉样变性的一个重要诊断依据。

关键词: 淀粉样变性, 牙龈, 舌, 活检, 诊断

Abstract: Objective：This study aimed to assess the significance of oral tissue biopsy in the diagnosis of amyloidosis . Methods: 38 patients were treated with oral tissue biopsy in past two years from 2010-05 to 2012-04. Among them, 30 cases underwent gingival tissue biopsy combined with 2 cases labial gland biopsy. 7 cases underwent tongue biopsy.1 case underwent lip biopsy. All specimen were dealt with HE staining and alkaline Congo red staining. Results: 13 cases were positively diagnosed with amyloidosis by oral tissue biopsy. In the 25 oral tissue negative cases, 2 were positively diagnosed by abdominal fat biopsy, 1 by forearm fat biopsy and 1 by kidney biopsy. Conclusion: Oral tissue biopsy is easy and simple to handle. The trauma is small and the recovery is rapid. So oral tissue biopsy can provide an important diagnostic foundation for amyloidosis.

Key words: amyloidosis, gingival, tongue, biopsy, diagnosis

中图分类号: 

• R781.6