摘要：

目的：探讨无水乙醇联合聚桂醇泡沫、平阳霉素治疗小儿颌面部静脉畸形的效果。方法：选取2016年5月—2020年9月在本院诊断为颌面部静脉畸形的患儿，采用随机数字表法将患儿分为对照组（n=49）与观察组（n=49）。对照组给予聚桂醇泡沫联合平阳霉素治疗，观察组给予无水乙醇联合聚桂醇泡沫、平阳霉素治疗。对比治疗前后瘤体面积的变化情况，并比较2组临床效果、复发率与不良反应发生情况。结果：与治疗前相比，治疗后2组患儿的平均瘤体面积减小（P<0.001），且观察组平均瘤体面积小于对照组（P<0.001）；2组治疗效果分布等级差异具有统计学意义（P<0.05），观察组总有效率高于对照组（P<0.05）；观察组复发率低于对照组（P<0.05）；观察组不良反应发生率为10.20%，对照组不良反应发生率为8.16%，2组对比差异无统计学意义（P>0.05）。结论：无水乙醇联合聚桂醇泡沫、平阳霉素治疗小儿颌面部静脉畸形可促进瘤体面积缩小，提升临床疗效，降低复发率，且具有一定的安全性。

关键词: 无水乙醇, 聚桂醇泡沫, 平阳霉素, 面部静脉畸形

Abstract:

Objective: To investigate the effectiveness of absolute ethanol combined with lauromacrogol foam and pingyangmycin in the treatment of maxillofacial venous malformations in children. Methods: Children with maxillofacial venous malformations treated in our hospital from May 2016 to September 2020 were included, and then were divided into control group(n=49) and observation group(n=49) by the random number table method. The control group was treated with lauromacrogol foam and pingyangmycin, while the observation group was given absolute ethanol combined with lauromacrogol foam and pingyangmycin. The changes of tumor size before and after treatment were statistically compared, and the clinical effects, recurrence rate, and adverse reactions were also compared. Results: Compared with average tumor size before treatment, the average tumor size of the two groups decreased after treatment (P<0.001), and the average tumor size of the observation group was smaller than that of the control group(P<0.001). There was significant difference in the grade distribution of therapeutic effect between the two groups(P<0.05), and the total effective rate of the observation group was higher than that of the control group(P<0.05). The recurrence rate of the observation group was lower than that of the control group(P<0.05). The incidence rate of adverse reactions in the observation group was 10.20% and 8.16% in the control group and no significant difference existed between the two groups(P>0.05). Conclusion: The treatment of maxillofacial venous malformations in children with absolute ethanol combined with lauromacrogol foam and pingyangmycin can promote the reduction of tumor size, enhance the clinical efficacy, and decrease the recurrence rate with certain safety.

Key words: absolute ethanol, lauromacrogol foam, pingyangmycin, maxillofacial venous malformation

中图分类号: 

• R782