摘要：

CCN1/CYR61（cellular communication network factor 1/cysteine-rich protein 61)是CCN家族成员，是一种重要的分泌基质蛋白。它在胚胎发育过程中对心血管的发育起着至关重要的作用；同时，在生物体成年期,其对炎症反应、血管生成、损伤修复、骨形成及过度纤维化和肿瘤等相关生理、病理过程起着关键作用。本文对CCN1/CYR61在骨再生中的作用作了简要总结，包括其对骨髓间充质干细胞、软骨细胞、成骨细胞及破骨细胞等骨再生相关细胞的调控，以及骨生成过程中必不可少的炎症反应和血管生成等生物学过程。

关键词: 基质细胞蛋白CCN1/CYR61, 骨再生, 炎症反应, 血管生成

Abstract:

CCN1/CYR61 (cellular communication network factor 1/cysteine-rich protein 61), a member of CCN family, is an important secretory matrix protein. It plays a vital role in the development of cardiovascular system during embryonic development, and plays a key role in the physiological and pathological processes related to inflammation, angiogenesis, damage repair, bone formation, excessive fibrosis and tumor in adulthood. This paper briefly summarized the role of CCN1/CYR61 in bone regeneration, including its regulation of bone regeneration related cells such as bone marrow mesenchymal stem cells, chondrocytes, osteoblasts and osteoclasts, as well as biological processes such as inflammation and angiogenesis, which are essential in the process of bone formation.

Key words: matricellular protein CCN1/CYR61, bone regeneration, inflammatory response, angiogenesis