口腔来源间充质干细胞对皮肤损伤修复再生影响的研究进展

doi:10.12439/kqhm.1005-4979.2026.04.011

《口腔颌面外科杂志》 ›› 2026, Vol. 36 ›› Issue (4): 342-347. doi: 10.12439/kqhm.1005-4979.2026.04.011

口腔来源间充质干细胞对皮肤损伤修复再生影响的研究进展

王化丽¹^,²(), 尹程程²^,³, 田文志¹^,², 王童¹^,², 孙泺咏¹^,², 孙宏晨¹^,²()

¹ 吉林大学口腔医院口腔病理科，长春　130021
² 吉林省口腔颅颌面疾病与组织重建重点实验室，长春　130021
³ 吉林大学口腔医院VIP综合科，长春　130021

收稿日期:2026-01-05 接受日期:2026-03-31 出版日期:2026-08-28 上线日期:2026-09-02
通讯作者: 孙宏晨，教授. E-mail: hcsun@mail.jlu.edu.cn
作者简介:
王化丽，硕士研究生. E-mail: huali23@mail.jlu.edu.cn
基金资助:
国家自然科学基金(82571066); 吉林省自然科学基金(20250101040JJ); 口颌系统重建与再生全国重点实验室开放课题(2024KA08)

Research progress on the effect of oral mesenchymal stem cells on skin injury repair and regeneration

WANG Huali¹^,²(), YIN Chengcheng²^,³, TIAN Wenzhi¹^,², WANG Tong¹^,², SUN Luoyong¹^,², SUN Hongchen¹^,²()

¹ Department of Oral Pathology, Hospital of Stomatology, Jilin University, Changchun 130021
² Jilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Changchun 130021
³ Department of VIP Comprehensive Dentistry, Hospital of Stomatology, Jilin University, Changchun 130021, China

Received:2026-01-05 Accepted:2026-03-31 Published:2026-08-28 Online:2026-09-02

摘要/Abstract

摘要：

皮肤损伤的功能性修复是当前亟待解决的临床难题，皮肤移植、创面敷料等传统治疗手段难以实现皮肤的功能性再生。近年来，干细胞疗法为该领域提供了新的研究方向。其中，口腔来源间充质干细胞（oral mesenchymal stem cells，OMSCs）具有易获取、多谱系分化潜能和无瘢痕修复特性等独特优势，是皮肤损伤修复领域极具潜力的细胞来源。本文综述了OMSCs在皮肤损伤修复中的独特优势、作用机制和应用潜力等最新研究进展。

关键词: 口腔来源间充质干细胞, 皮肤伤口愈合, 免疫调节, 无瘢痕, 组织再生

Abstract:

The functional repair of skin injury remains a significant challenge in the clinic. Conventional treatments, such as skin grafting and wound dressings, often fail to achieve functional regeneration. In recent years, stem cell-based therapies have emerged as a promising strategy in this field. Among them, oral mesenchymal stem cells (OMSCs) have attracted considerable attention due to their unique advantages, including easy accessibility, multilineage differentiation capacity, and scarless regenerative potential. These properties make OMSCs a highly promising cell source for skin wound repair. This review summarizes recent advances in the distinctive advantages, underlying mechanisms, and the therapeutic potential of OMSCs in skin injury repair.

Key words: oral mesenchymal stem cells, skin wound healing, immunomodulation, scarless, tissue regeneration

王化丽, 尹程程, 田文志, 王童, 孙泺咏, 孙宏晨. 口腔来源间充质干细胞对皮肤损伤修复再生影响的研究进展[J]. 《口腔颌面外科杂志》, 2026, 36(4): 342-347.

WANG Huali, YIN Chengcheng, TIAN Wenzhi, WANG Tong, SUN Luoyong, SUN Hongchen. Research progress on the effect of oral mesenchymal stem cells on skin injury repair and regeneration[J]. Journal of Oral and Maxillofacial Surgery(CN), 2026, 36(4): 342-347.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2026/V36/I4/342

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口腔来源间充质干细胞对皮肤损伤修复再生影响的研究进展

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