Recent Advances on Primary Cilia in Stem Cell Differentiation and Tooth Development

doi:10.3969/j.issn.1005-4979.2019.04.009

Abstract

Abstract: Primary cilia, a special organelle protruding from the cell surface, consisting of a spindle filament and a specialized membrane and matrix surrounding it, which have the function of sensing external mechanical stimulation and biochemical signals. Primary cilia play an important role in stem cell self-renewal, lineage differentiation and fate decision. Most of the epithelial and mesenchymal cells of developing tooth germ have primary cilia, and the length of cilia changes significantly during the development process. In recent years, the role of primary cilia in the development of teeth and the differentiation of mesenchymal stem cells has attracted more attention. Further research in this area will deepen the understanding of the tooth growth mechanism and promote the development of tooth regeneration.

Key words: primary cilia, dental mesenchymal stem cells, tooth development

摘要： 初级纤毛是突出于细胞表面的一种特殊细胞器，由一根轴丝及包绕在其周围特化的细胞膜和基质组成，具有感受外界机械刺激和生物化学信号的功能。初级纤毛在干细胞自我更新，谱系分化和命运决定中均发挥重要作用。发育中的牙胚上皮和间充质细胞大多具有初级纤毛，而且纤毛的长度随着发育进程出现显著的变化。近年来，初级纤毛在牙发育及牙间充质干细胞分化中的作用逐渐受人关注，深入了解该方面的研究进展有望加深对牙发育机理的认识，以及促进牙再生领域的发展。

CLC Number:

R782

ZHOU Shuang, ZHOU Ting-ting, SUN Yao. Recent Advances on Primary Cilia in Stem Cell Differentiation and Tooth Development[J]. 《Journal of Oral and Maxillofacial Surgery》, doi: 10.3969/j.issn.1005-4979.2019.04.009.

周爽，周婷婷（综述），孙瑶（审校）. 初级纤毛与干细胞分化及牙发育相关研究进展[J]. 《口腔颌面外科杂志》, doi: 10.3969/j.issn.1005-4979.2019.04.009.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.3969/j.issn.1005-4979.2019.04.009

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2019/V29/I4/230

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