NTRK-rearranged spindle cell tumor in oral and maxillofacial region: A case report and literature review

doi:10.12439/kqhm.1005-4979.2025.02.012

《Journal of Oral and Maxillofacial Surgery》 ›› 2025, Vol. 35 ›› Issue (2): 153-156. doi: 10.12439/kqhm.1005-4979.2025.02.012

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NTRK-rearranged spindle cell tumor in oral and maxillofacial region: A case report and literature review

SUN Yucheng¹^,²(), CAO Zhang³, LI Jianwei², WANG Wenlong², WANG Yuliang¹()

¹ Department of Oral and Maxillofacial Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100
² Department of Oral and Maxillofacial Surgery, Binzhou 256600, China
³ Department of Pathology, Binzhou Medical University Hospital, Binzhou 256600, China

Received:2023-08-31 Accepted:2024-03-22 Published:2025-04-28 Online:2025-04-28

口腔颌面部NTRK重排梭形细胞肿瘤1例报告及文献复习

孙钰程¹^,²(), 曹璋³, 李建卫², 王文龙², 王玉良¹()

¹ 滨州医学院烟台附属医院口腔颌面外科，烟台　264100
² 滨州医学院附属医院口腔颌面外科，滨州　256600
³ 滨州医学院附属医院口腔颌面病理科，滨州　256600

通讯作者: 王玉良，教授. E-mail:yuliangwang@bzmc.edu.cn
作者简介:
孙钰程，住院医师. E-mail:19812500642@163.com
基金资助:
山东省自然科学基金(ZR2019PH075)

Abstract

Abstract:

Neurotrophin receptor kinase (NTRK)-rearranged spindle cell tumor is a new and rare soft tissue tumor. This article reports a case of NTRK-rearranged spindle cell tumor in the left cheek and aims to improve awareness of the disease and reduce clinical misdiagnosis.

Key words: neurotrophin receptor kinase, spindle cell tumor, oral and maxillofacial region

摘要：

神经营养因子受体络氨酸基酶（neurotrophin receptor kinase，NTRK）重排梭形细胞肿瘤是一种新型罕见软组织肿瘤，本文报道1例发生于左侧颊部的NTRK重排梭形细胞肿瘤，旨在提高临床医生对该病的认识，减少误诊。

关键词: 神经营养因子受体络氨酸基酶, 梭形细胞肿瘤, 口腔颌面部

CLC Number:

R782

SUN Yucheng, CAO Zhang, LI Jianwei, WANG Wenlong, WANG Yuliang. NTRK-rearranged spindle cell tumor in oral and maxillofacial region: A case report and literature review[J]. 《Journal of Oral and Maxillofacial Surgery》, 2025, 35(2): 153-156.

孙钰程, 曹璋, 李建卫, 王文龙, 王玉良. 口腔颌面部NTRK重排梭形细胞肿瘤1例报告及文献复习[J]. 《口腔颌面外科杂志》, 2025, 35(2): 153-156.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2025.02.012

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2025/V35/I2/153

Figures/Tables 5

Figure 1 Clinical appearance of the tumor

Figure 2 Imageological examination before surgery

Figure 3 The intraoperative photo, tumor specimen and the postoperative photo

Figure 4 Pathological features and immunohistochemical expression of the tumor（×100）

Figure 5 Postoperative follow-up photo and imaging results

References 9

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