摘要：

目的：探讨牙骨质-骨结构不良（cemento-osseous dysplasias，COD）的临床诊疗特点。方法：收集经手术治疗的21例COD患者的临床诊疗资料，对患者的临床表现（年龄、性别、部位、症状和体征等）、影像学特征、术中情况及预后等进行回顾性分析。结果：21例COD患者中，女性发病率高于男性，40~49岁为好发年龄，约占52.4%；52.4%的患者无临床症状，病变好发于下颌骨，骨质隆起、牙齿缺失为常见体征，占57.1%；38.5%的病变造成下颌管移位，均未出现下唇麻木，30.8%的病变造成邻近牙齿牙根吸收；影像学上，69.2%的病变以透射影为主，30.8%的病变以阻射影为主；手术治疗为该病的有效治疗手段，术后病变区均显示骨形成。结论：COD是一种少见的颌骨结构异常，女性患者发病率明显高于男性，下颌骨较上颌骨多见，多数患者无临床症状，部分可发生感染症状，手术切除病变有利于骨质重新形成，是治疗该病的有效手段。

关键词: 牙骨质-骨结构不良, 颌骨, 骨化纤维瘤, 回顾性分析

Abstract:

Objective: To investigate the clinical characteristics of cemento-osseous dysplasia(COD). Methods: The clinical diagnostic and treatment data of 21 patients with COD were collected. The clinical manifestations (age, gender, location, symptoms and signs), imaging characteristics, intraoperative conditions and prognosis were recorded and analyzed retrospectively. Results: Among the 21 cases, the incidence rate of female were higher than that of male, and 40-49 years old was the predilection age, accounting for 52.4%. 52.4% of the patients had no clinical symptoms. The lesions mostly located in mandible. Cortical bone expansion and missing teeth were common signs, accounting for 57.1%. 38.5% of the lesions caused mandibular canal displacement without lower lip numbness, and 30.8% of the lesions caused root resorption of the adjacent teeth. In radiological imaging, 69.2% of the lesions were mainly transparent and 30.8% were mainly resistant. Surgical treatment was effective for the disease, and new bone formation is found in the lesion area after operation. Conclusion: COD is a rare structural disorder of jaw. The incidence rate in female patients is significantly higher than that of male. It has a predilection for the mandible. Most patients have no clinical symptoms, and some infections can occur. Surgical resection is beneficial for bone regeneration.

Key words: cemento-osseous dysplasias, jaw, ossifying fibroma, retrospective analysis

中图分类号: 

• R782