Prrx1在骨发育和骨改建中作用的研究进展

doi:10.12439/kqhm.1005-4979.2023.05.010

《口腔颌面外科杂志》 ›› 2023, Vol. 33 ›› Issue (5): 336-338. doi: 10.12439/kqhm.1005-4979.2023.05.010

Prrx1在骨发育和骨改建中作用的研究进展

冯曦(), 王佐林()

同济大学口腔医学院，同济大学附属口腔医院口腔种植科，上海牙组织修复与再生工程技术研究中心，上海　200072

收稿日期:2022-02-21 接受日期:2022-04-27 出版日期:2023-10-28 发布日期:2023-11-03
通讯作者: 王佐林，教授. E-mail: zuolin@tongji.edu.cn
作者简介:
冯曦，硕士研究生. E-mail: 270495019@qq.com
基金资助:
国家自然科学基金(81670962); 国家重点研发计划(2018YFE0202200); 中央高校基本业务费专项基金(22120180196)

Recent advances of the role of Prrx1 in bone development and bone remodeling

FENG Xi(), WANG Zuolin()

Department of Implantology, Stomatological Hospital and Dental School of Tongji University, ShanghaiEngineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, China

Received:2022-02-21 Accepted:2022-04-27 Online:2023-10-28 Published:2023-11-03

摘要/Abstract

摘要：

转录因子配对相关同源框1（paired related homeobox 1，Prrx1）作为一种间充质细胞的标志物，不仅参与胚胎时期的骨发育过程，亦在机体成年后骨稳态的调节与损伤后的修复过程中发挥作用。Prrx1⁺细胞是间充质细胞的一种亚群，作为成骨的前体细胞参与骨骼的发育与形成。本文对Prrx1及Prrx1⁺细胞在骨发育及骨改建中的作用及影响进行综述。

关键词: 配对相关同源框1, Prrx1⁺细胞, 骨发育, 骨改建

Abstract:

As a marker of mesenchymal cells, the transcription factor paired related homeobox 1 (Prrx1) not only participates in the bone development process during the embryonic period, but also plays a role in the adjustment of the body's bone homeostasis and the repair process after injury in adulthood. Prrx1⁺ cells are a subpopulation of the body's mesenchymal cells, which are believed to be involved in the development and formation of long bones and skulls as osteogenic precursor cells. This article reviews the role and influence of Prrx1 and Prrx1⁺ cells in bone development and bone remodeling.

Key words: paired related homeobox 1, Prrx1⁺ cells, bone development, bone remodeling

中图分类号:

R782

冯曦, 王佐林. Prrx1在骨发育和骨改建中作用的研究进展[J]. 《口腔颌面外科杂志》, 2023, 33(5): 336-338.

FENG Xi, WANG Zuolin. Recent advances of the role of Prrx1 in bone development and bone remodeling[J]. 《Journal of Oral and Maxillofacial Surgery》, 2023, 33(5): 336-338.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2023/V33/I5/336

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