《口腔颌面外科杂志》 ›› 2025, Vol. 35 ›› Issue (3): 219-222. doi: 10.12439/kqhm.1005-4979.2025.03.008

• 综述 • 上一篇    下一篇

骨骼干细胞的研究进展

陈晓帆,王佐林   

  1. 上海市同济口腔医院口腔种植科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海 200072

  • 出版日期:2025-06-28 上线日期:2025-06-27

Research advances in skeletal stem cells

CHEN Xiaofan, WANG Zuolin   

  1. Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral Implantology, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, China

  • Published:2025-06-28 Online:2025-06-27

摘要:

骨骼系统的生长发育、稳态维持和损伤修复依赖于骨干祖细胞的持续增殖和分化。尽管骨髓间充质干细胞(bone marrow mesenchymal stem cellsBMSCs)的研究在过去的几十年中已积累较多进展,但是骨骼干细胞(skeletal stem cellsSSCs)的定义和标志物仍然存在争议。近年来,谱系示踪和生物信息学相关技术的进步,推动了 SSCs 的纯化分离和功能研究。本文系统综述了不同来源和标志物的 SSCs 类群及其在骨骼发育和修复中的功能。

关键词:

骨骼干细胞, 骨髓间充质干细胞, 骨修复, 骨发育

Abstract:

The development, homeostasis maintenance, and damage repair of the skeletal system require continuous proliferation and differentiation of stem and progenitor cells. Although studies on bone marrow mesenchymal stem cells (BMSCs) have accumulated substantial evidence over the past decades, the definition and markers of skeletal stem cells (SSCs) remain controversial. Recent advances in lineage tracing and bioinformatics technologies have facilitated the purification and functional investigation of SSCs. This review systematically summarizes different SSC populations based on their origins and markers, as well as their functions in skeletal development and repair.

Key words:

skeletal stem cells, bone marrow mesenchymal stem cells, bone repair, bone development

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