不同腮腺症状原发性舍格伦综合征的血清学分析

doi:10.3969/j.issn.1005-4979.2015.01.007

《口腔颌面外科杂志》 ›› 2015, Vol. 25 ›› Issue (1): 39-. doi: 10.3969/j.issn.1005-4979.2015.01.007

不同腮腺症状原发性舍格伦综合征的血清学分析

曹宁宁，郑凌艳，俞创奇，谢李松，石欢，王知俊

上海交通大学医学院附属第九人民医院口腔颌面外科，上海市口腔医学重点实验室，上海 200011

出版日期:2015-02-28 发布日期:2015-04-29
通讯作者: 郑凌艳，副主任医师. E-mail:zhenglingyan73@163.com
作者简介:曹宁宁（1991—），男，山东济宁人，硕士研究生.
基金资助:
国家自然科学基金资助项目(81100766)；上海市重点学科建设项目（S30206）

The Correlation between Serological Profiles and Clinical Features of
Parotid Glands in Primary Sjogren’s Syndrome

CAO Ning-ning, ZHENG Ling-yan, YU Chuang-qi, XIE Li-song, SHI Huan, WANG Zhi-jun

Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China

Online:2015-02-28 Published:2015-04-29

摘要/Abstract

摘要： 目的：研究不同腮腺症状的原发性舍格伦综合征（ primary Sj?觟gren’s syndrome，pSS）患者之间的血清学特征的差异性。方法：回顾性研究289名患者，均符合原发性舍格伦综合征（2002年修订的欧美联合诊断标准）。依据患者腮腺的临床特征，将患者分为以下4组：第1组（类肿瘤组）、第2组（感染组）、第3组（肿大组）、第4组（口干组）。对比各组之间的人口统计学和血清学特征。每两组之间结果的统计学分析用t检验，F检验，卡方检验，方差分析。结果：不同的腮腺临床特征的pSS患者具有不同的血清学表型。第1组的血清免疫球蛋白IgG值是4组中最高的，而补体C4是4组中最低的。第2组的血清免疫球蛋白IgE值是4组中最高的。第3组的血沉值是4组中最高的。结论：不同腮腺临床症状的pSS患者具有不同的血清学表型。这可能有助于增进我们对该疾病的认识。

关键词: 原发性舍格伦综合征； , 血清学表型； , 腮腺

Abstract: Objective: To investigate the differences of serological profiles in primary Sjogren’s Syndrome (pSS) and evaluate their correlation with the clinical characteristics of parotid glands. Methods: The retrospective study included 289 patients who fulfilled the diagnosis for pSS adviced by American-European Consensus Group Criteria in 2002. The patients were categorized by the clinical features of parotid glands: group1 (massive group), group 2 (infection group), group 3 (swelling group) and group 4 (others). The demographic data and serological profiles among these groups were compared. Statistical analyses of the results between groups were performed using the Student t test, Fisher's exact test, chi-square and analysis of variance. Results: There was differences of serological profiles in accordance with the different clinical characteristics of parotid glands of pSS patients. Serum IgG value in Group 1 was the greatest, and complement C4 was lowest in four groups. Serum IgE value in Group 2 was the greatest and ESR in Group 3 was the greatest among the four groups. Conclusion: This study demonstrates the differences of serological profile in different clinical features of parotid glands of pSS patients, which may be benefit to advance our understanding of the disease.

Key words: [Keywords] , primary Sjogren’s syndrome, serological profiles, parotid gland

中图分类号:

R781.77

曹宁宁，郑凌艳，俞创奇，谢李松，石欢，王知俊. 不同腮腺症状原发性舍格伦综合征的血清学分析[J]. 《口腔颌面外科杂志》, 2015, 25(1): 39-.

CAO Ning-ning, ZHENG Ling-yan, YU Chuang-qi, XIE Li-song, SHI Huan, WANG Zhi-jun. The Correlation between Serological Profiles and Clinical Features of
Parotid Glands in Primary Sjogren’s Syndrome[J]. 《Journal of Oral and Maxillofacial Surgery》, 2015, 25(1): 39-.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2015/V25/I1/39

参考文献

[1] Fox RI, Stern M, Michelson P.Update in Sjogren syndrome[J]. Curr Opin Rheumatol, 2000, 12(5):391-398.

[2] Mavragani CP, Moutsopoulos HM. The geoepidemiology of Sjogren's syndrome[J]. Autoimmun Rev, 2010, 9(5):A305-A310.

[3] Li CL, He J, Li ZG, et al. Effects of total glucosides of paeony for delaying onset of Sjogren's syndrome: an animal study[J]. J Craniomaxillofac Surg, 2013, 41(7):610-615.

[4] Dafni UG, Tzioufas AG, Staikos P, et al. Prevalence of Sjogren's syndrome in a closed rural community[J]. Ann Rheum Dis, 1997, 56(9):521-525.

[5] Bowman SJ, Ibrahim GH, Holmes G, et al. Estimating the prevalence among Caucasian women of primary Sjogren's syndrome in two general practices in Birmingham, UK[J]. Scand J Rheumatol, 2004, 33(1):39-43.

[6] Xiang YJ, Dai SM. Prevalence of rheumatic diseases and disability in China[J]. Rheumatol Int, 2009, 29(5):481-490.

[7] Bournia VK, Vlachoyiannopoulos PG. Subgroups of Sjogren syndrome patients according to serological profiles [J]. J Autoimmun, 2012, 39(1-2):15-26.

[8] Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group [J]. Ann Rheum Dis, 2002, 61(6):554-558.

[9] Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjogren syndrome[J]. Arch Intern Med,2004,164(12):1275-1284.

[10] Yilmaz YF, Titiz A, Yurur-Kutlay N, et al. Congenital bilateral parotid gland agenesis in Klinefelter syndrome [J]. J Craniomaxillofac Surg, 2010, 38(4):248-250.

[11] Longman LP, Higham SM, Bucknall R, et al. Signs and symptoms in patients with salivary gland hypofunction [J]. Postgrad Med J, 1997,73(856):93-97.

[12] Zheng LY, Kim E, Yu CQ, et al. A retrospective case series illustrating a possible association between a widened hilum and sialolith formation in the submandibular gland[J]. J Craniomaxillofac Surg, 2013, 41(7):648-651.

[13] Flaitz CM. Parotitis as the initial sign of juvenile Sjogren's syndrome [J]. Pediatr Dent, 2001, 23(2):140-142.

[14] Mignogna MD, Fedele S, Lo Russo L, et al. Sjogren's syndrome: the diagnostic potential of early oral manifestations preceding hyposalivation/xerostomia [J]. J Oral Pathol Med, 2005, 34(1):1-6.

[15] Scully C, Georgakopoulou EA. Oral Involvement[M]// Ramos-Casals M, Stone J H, Moutsopoulos HM. Sjogren's Syndrome.London: Springer-Verlag, 2012: 86-102.

[16] Tzioufas AG, Tatouli IP, Moutsopoulos HM. Autoantibodies in Sjogren's syndrome: clinical presentation and regulatory mechanisms [J]. Presse Med, 2012, 41(9 Pt 2):e451-e460.

[17] Huo AP, Lin KC, Chou CT. Predictive and prognostic value of antinuclear antibodies and rheumatoid factor in primary Sjogren's syndrome[J]. Int J Rheum Dis, 2010, 13(1):39-47.

[18] Menéndez A, Gómez J, Escanlar E, et al. Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies: Diagnostic utility of their separate detection[J]. Autoimmunity, 2013, 46(1):32-39.

[19] Yoshimi R, Ueda A, Ozato K, et al. Clinical and pathological roles of Ro/SSA autoantibody system [J]. Clin Dev Immunol, 2012, 2012:606195.

[20] Yazisiz V, Avci AB, Erbasan F, et al. Diagnostic performance of minor salivary gland biopsy, serological and clinical data in Sjogren's syndrome: a retrospective analysis[J]. Rheumatol Int, 2009, 29(4):403-409.

[21] Brito-Zerón P, Pérez-Alvarez R, Pérez-de-Lis M. Laboratory abnormalities in primary Sjogren's syndrome[M]// Ramos-Casals M, Stone J H, Moutsopoulos HM. Sjogren's Syndrome. London: Springer-Verlag, 2012: 348-360.

[22] Friedman J, Klepfish A, Miller EB, et al. Agranulocytosis in Sjogren's syndrome: two case reports and analysis of 11 additional reported cases[J]. Semin Arthritis Rheum, 2002, 31(5):338-345.

[23] Ramos-Casals M, Font J, Garcia-Carrasco M, et al. Primary Sjogren syndrome: hematologic patterns of disease expression [J]. Medicine (Baltimore), 2002, 81(4):281-292.

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不同腮腺症状原发性舍格伦综合征的血清学分析

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The Correlation between Serological Profiles and Clinical Features of
Parotid Glands in Primary Sjogren’s Syndrome