Nrf2在口腔医学领域的研究进展

doi:10.3969/j.issn.1005-4979.2022.03.010

《口腔颌面外科杂志》 ›› 2022, Vol. 32 ›› Issue (3): 192-195. doi: 10.3969/j.issn.1005-4979.2022.03.010

Nrf2在口腔医学领域的研究进展

胡丹丹(), 程楚男, 苏俭生()

上海牙组织修复与再生工程技术研究中心，同济大学口腔医学院，同济大学附属口腔医院口腔修复教研室，上海 200072

收稿日期:2021-02-23 修回日期:2021-03-02 出版日期:2022-06-28 发布日期:2022-06-29
通讯作者: 苏俭生，教授. E-mail: sjs@tongji.edu.cn
作者简介:
胡丹丹（1988—），女，江苏人，博士研究生. E-mail: 1910876@tongji.edu.cn
基金资助:
国家自然科学基金(81572114); 国家自然科学基金(81873715)

Research advances of Nrf2 in stomatology

HU Dandan(), CHENG Chunan, SU Jiansheng()

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Prosthodontics, School and Hospital of Stomatology, Tongji University, Shanghai 200072, China

Received:2021-02-23 Revised:2021-03-02 Online:2022-06-28 Published:2022-06-29

摘要/Abstract

摘要：

核因子E2相关因子2（nuclear factor E2-related factor 2，Nrf2）是转录因子家族中的重要蛋白，其分子量为66 kDa。近年来，在Nrf2的活性调控、下游途径和对疾病发展的影响等方面取得了重大的研究进展，但其在口腔疾病方面的研究进展鲜有报道，本文就Nrf2在口腔疾病方面的研究进展作一综述。

关键词: 核因子E2相关因子2, 牙周炎, 口腔癌

Abstract:

Nuclear factor E2-related factor 2(Nrf2) is an important protein in the transcription factor family, with a molecular weight of 66 kDa. In recent years, with the progress of research, significant research progresses have been made in the activity regulation, downstream pathway of Nrf2 and its effect on disease development, but few progresses in field of oral diseases are reported. In this paper, the research progress of Nrf2 within the field of oral diseases is reviewed.

Key words: nuclear factor E2-related factor 2, periodontitis, oral cancer

胡丹丹, 程楚男, 苏俭生. Nrf2在口腔医学领域的研究进展[J]. 《口腔颌面外科杂志》, 2022, 32(3): 192-195.

HU Dandan, CHENG Chunan, SU Jiansheng. Research advances of Nrf2 in stomatology[J]. 《Journal of Oral and Maxillofacial Surgery》, 2022, 32(3): 192-195.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2022/V32/I3/192

图/表 1

参考文献 30

[1]	Moi P, Chan K, Asunis I, et al. Isolation of NF-E2-related factor 2(Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region[J]. PNAS, 1994, 91(21): 9926-9930. doi: 10.1073/pnas.91.21.9926 pmid: 7937919
[2]	Tonelli C, Chio IIC, Tuveson DA. Transcriptional regulation by Nrf2[J]. Antioxid Redox Signal, 2018, 29(17): 1727-1745. doi: 10.1089/ars.2017.7342 URL
[3]	Itoh K, Igarashi K, Hayashi N, et al. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins[J]. Mol Cell Biol, 1995, 15(8): 4184-4193. doi: 10.1128/MCB.15.8.4184 pmid: 7623813
[4]	Guo Y, Yu SW, Zhang CY, et al. Epigenetic regulation of Keap1-Nrf2 signaling[J]. Free Radic Biol Med, 2015, 88: 337-349. doi: 10.1016/j.freeradbiomed.2015.06.013 URL
[5]	Baird L, Swift S, Llères D, et al. Monitoring Keap1-Nrf2 interactions in single live cells[J]. Biotechnol Adv, 2014, 32(6): 1133-1144. doi: 10.1016/j.biotechadv.2014.03.004 pmid: 24681086
[6]	Slots J. Periodontitis: Facts, fallacies and the future[J]. Periodontol 2000, 2017, 75(1): 7-23. doi: 10.1111/prd.2017.75.issue-1 URL
[7]	Onizuka S, Iwata T. Application of periodontal ligament-derived multipotent mesenchymal stromal cell sheets for periodontal regeneration[J]. Int J Mol Sci, 2019, 20(11): 2796. doi: 10.3390/ijms20112796 URL
[8]	Ying SQ, Tan MM, Feng G, et al. Low-intensity pulsed ultrasound regulates alveolar bone homeostasis in experimental periodontitis by diminishing oxidative Stress[J]. Theranostics, 2020, 10(21): 9789-9807. doi: 10.7150/thno.42508 pmid: 32863960
[9]	Liu YL, Yang HX, Wen Y, et al. Nrf2 inhibits periodontal ligament stem cell apoptosis under excessive oxidative stress[J]. Int J Mol Sci, 2017, 18(5): 1076. doi: 10.3390/ijms18051076 URL
[10]	Jia LL, Xiong YX, Zhang WJ, et al. Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway[J]. Exp Cell Res, 2020, 386(2): 111717. doi: 10.1016/j.yexcr.2019.111717 URL
[11]	Huang CC, Zhang CT, Yang PP, et al. Eldecalcitol inhibits LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2/HO-1 signaling pathway[J]. Drug Des Devel Ther, 2020, 14: 4901-4913. doi: 10.2147/DDDT.S269223 URL
[12]	Kim S, Choi SI, Kim GH, et al. Anti-inflammatory effect of Ecklonia cava extract on Porphyromonas gingivalis lipopolysaccharide-stimulated macrophages and a periodontitis rat model[J]. Nutrients, 2019, 11(5): 1143. doi: 10.3390/nu11051143 URL
[13]	Bhattarai G, Poudel SB, Kook SH, et al. Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis[J]. Acta Biomater, 2016, 29: 398-408. doi: S1742-7061(15)30161-6 pmid: 26497626
[14]	Fischhuber KM, Matzinger M, Heiss E. AMPK enhances transcription of selected Nrf2 target genes via negative regulation of Bach1[J]. Frontiers in cell and developmental biology, 2020, 8:628. doi: 10.3389/fcell.2020.00628 pmid: 32760724
[15]	Kanzaki H, Shinohara F, Itohiya K, et al. RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice[J]. FASEB J, 2017, 31(2): 781-792. doi: 10.1096/fj.201600826R pmid: 27836987
[16]	Li J, Li YP, Pan S, et al. Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-κB/NFATc1 signaling pathway[J]. Biochimie, 2019, 156: 129-137. doi: S0300-9084(18)30264-5 pmid: 30213522
[17]	Liu H, Dong YH, Gao YT, et al. Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss[J]. J Cell Physiol, 2019, 234(7): 11009-11022. doi: 10.1002/jcp.27924 pmid: 30548260
[18]	Yamaguchi Y, Kanzaki H, Katsumata Y, et al. Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation[J]. J Cell Mol Med, 2018, 22(2): 1138-1147. doi: 10.1111/jcmm.13367 pmid: 29063666
[19]	Narimiya T, Kanzaki H, Yamaguchi Y, et al. Nrf2 activation in osteoblasts suppresses osteoclastogenesis via inhibiting IL-6 expression[J]. Bone Rep, 2019, 11: 100228.
[20]	Primus CM, Tay FR, Niu LN. Bioactive tri/dicalcium silicate cements for treatment of pulpal and periapical tissues[J]. Acta Biomater, 2019, 96: 35-54. doi: S1742-7061(19)30377-0 pmid: 31146033
[21]	Kim D, Kim H, Kim K, et al. The protective effect of indole-3-acetic acid (IAA) on H2O 2-damaged human dental pulp stem cells is mediated by the AKT pathway and involves increased expression of the transcription factor nuclear factor-erythroid 2-related factor 2(Nrf2) and its downstream target heme oxygenase 1 (HO-1)[J]. Oxid Med Cell Longev, 2017, 2017: 8639485.
[22]	Menegon S, Columbano A, Giordano S. The dual roles of NRF2 in cancer[J]. Trends Mol Med, 2016, 22(7): 578-593. doi: S1471-4914(16)30026-0 pmid: 27263465
[23]	贾宝超, 关键, 戴辛鹏, 等. Nrf2、HO-1在口腔鳞癌组织中的表达及其临床意义[J]. 口腔医学研究, 2017, 33(2): 207-210. doi: 10.13701/j.cnki.kqyxyj.2017.02.022
[24]	吴智华, 朱逸文, 余东升. Nrf2及Keap1蛋白在舌鳞状细胞癌中的表达及临床意义[J]. 临床口腔医学杂志, 2019, 35(12): 715-718.
[25]	付洁, 宿颖, 关晓兵, 等. 三氧化二砷对口腔鳞癌细胞系Nrf2通路的激活作用[J]. 北京口腔医学, 2012, 20(5): 260-265.
[26]	Sharma Y, Bharadwaj M, Srivastava N, et al. In vitro antioxidant activity of defatted seed extracts of Ocimum sanctum on rat PC-12 cells and its inhibitory efficacy with receptors of oral squamous cell carcinoma[J]. Ind Crops Prod, 2020, 154: 112668. doi: 10.1016/j.indcrop.2020.112668 URL
[27]	Panigrahi DP, Bhol CS, Nivetha R, et al. Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway[J]. Int J Biol Macromol, 2020, 155: 1123-1132. doi: S0141-8130(19)35707-1 pmid: 31715238
[28]	de Souza RF, Lovato da Silva CH, Nasser M, et al. Interventions for the management of temporomandibular joint osteoarthritis[J]. Cochrane Database Syst Rev, 2012, 2012(4): CD007261.
[29]	Jiang C, Luo P, Li X, et al. Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation[J]. Cell Stress Chaperones, 2020, 25(3): 395-406. doi: 10.1007/s12192-020-01079-z
[30]	Wati SM, Matsumaru D, Motohashi H. Nrf2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands[J]. Redox Biol, 2020, 36: 101603. doi: 10.1016/j.redox.2020.101603 URL

选择文件类型/文献管理软件名称

选择包含的内容

Nrf2在口腔医学领域的研究进展

Research advances of Nrf2 in stomatology

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

图/表 1

参考文献 30

相关文章 15

编辑推荐

Metrics

本文评价

[1]	郑章龙, 李家, 姜吉蕊, 单铮男, 李生娇. 坏死性凋亡对牙周炎免疫微环境的影响机制初探[J]. 《口腔颌面外科杂志》, 2023, 33(5): 298-304.
[2]	陈栋怡, 苏俭生. LincRNA-EPS对牙周炎小鼠肠道菌群影响的实验研究[J]. 《口腔颌面外科杂志》, 2023, 33(3): 138-147.
[3]	任乐, 魏玉, 马鹏飞, 易紫媚, 赵洁晨, 吴珺华. 炎性牙周膜干细胞影响T细胞迁移及活化的初步研究[J]. 《口腔颌面外科杂志》, 2023, 33(3): 148-154.
[4]	黄碧莹, 张强. 尼古丁在口腔癌发生、发展中的作用机制及研究进展[J]. 《口腔颌面外科杂志》, 2023, 33(1): 46-48.
[5]	黄梓校, 崔子威, 郭茹, 周红丽, 王涛, 何祥一. 沉默Livin基因增加5-氟尿嘧啶诱导Cal27凋亡敏感性的研究[J]. 《口腔颌面外科杂志》, 2022, 32(6): 354-361.
[6]	柴加传，许彪，夏斌，罗磊. 外周血NLR、PLR、LMR在口腔鳞状细胞癌辅助诊断中的价值探讨[J]. 《口腔颌面外科杂志》, 2021, 31(5): 298-.
[7]	张杰1，孙强2，葛良玉3，孟箭3. 薄型股前外侧皮瓣与前臂皮瓣修复老年口腔癌切除术后缺损的效果比较[J]. 《口腔颌面外科杂志》, 2021, 31(5): 319-.
[8]	王锦锋，秦红霞. 探讨葛根素基于p38丝裂原活化蛋白激酶通路对慢性牙周炎小鼠症状的改善作用及对牙周组织生长的影响[J]. 《口腔颌面外科杂志》, 2021, 31(4): 207-.
[9]	李琴，王佐林. TREM-2/DAP12复合物在牙周炎中的作用及研究进展[J]. 《口腔颌面外科杂志》, 2021, 31(2): 110-.
[10]	叶远舟，刘凯,王雅冰,苏俭生. LincRNA-EPS对脂多糖诱导的小鼠牙周膜细胞炎症因子表达的影响[J]. 《口腔颌面外科杂志》, 2021, 31(1): 1-8.
[11]	胡安妮，苏俭生. LncRNA参与固有免疫及其在牙周炎症反应中的研究进展[J]. 《口腔颌面外科杂志》, 2021, 31(1): 52-55.
[12]	周钰伟，黄子贤，黄志权. 口腔癌术后吞咽困难的相关因素、评估及术后护理[J]. 《口腔颌面外科杂志》, 2021, 31(1): 60-64.
[13]	吴淋，董迎春. 右美托咪定对口腔癌术后患者留置气管导管耐受性的影响[J]. 《口腔颌面外科杂志》, 2021, 31(1): 24-27.
[14]	翦新春，高兴，谭茜. 口腔黏膜下纤维性变的成因及癌变的相关性研究[J]. 《口腔颌面外科杂志》, 2020, 30(4): 195-.
[15]	张雪，赵保建，邵博明，董迎春. 体温保护对口腔癌患者术后加速康复的影响[J]. 《口腔颌面外科杂志》, 2020, 30(2): 102-.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Nrf2在口腔医学领域的研究进展

Research advances of Nrf2 in stomatology

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

图/表 1

参考文献 30

相关文章 15

编辑推荐

Metrics

本文评价