摘要：

软骨发育是一个复杂精细的过程，过程中的任何阶段受到干扰都可能会引发严重的后果。尽管已有关于软骨的结构、发育过程、发育异常及相关的调控机制的大量研究，但软骨发育异常仍有许多调控因素未被发现，现有的研究也缺乏系统的归类。软骨细胞肥大进程在软骨发育过程中占据十分重要的地位，其过程受到多种因素的调控，如激素、表观遗传、信号通路、离子通道等。本文聚焦于软骨细胞肥大阶段，综述了调控软骨细胞肥大进程的各种因素，以及其在颌面部发育的重要影响，为今后研究软骨发育和相关疾病的防治提供新的研究思路和方向。

关键词: 软骨, 细胞肥大, 颌骨, 调控因素

Abstract:

Cartilage development is a complex and delicate process, and any stage of which is disturbed may cause serious consequences. Although a large amount of work has been studied in the specific structure and development process of cartilage, cartilage dysplasia and related regulatory mechanisms, there are still many regulatory factors in cartilage dysplasia that have not been discovered, and current studies lack a systematic classification. The process of chondrocyte hypertrophy, which is regulated by many factors, such as hormones, epigenetics, signal pathways, ion channels, etc, occupies a very important position in the process of cartilage development. This article focuses on the stage of chondrocyte hypertrophy, and reviews the various factors that regulate the process of chondrocyte hypertrophy and their important impact on maxillofacial bone development. It will provide new research ideas and directions for future research on the prevention and treatment of cartilage development and related diseases.

Key words: cartilage, cell hypertrophy, mandibular, regulation factor