CCN2在软骨内成骨过程中作用的研究进展

doi:10.3969/j.issn.1005-4979.2014.06.016

《口腔颌面外科杂志》 ›› 2014, Vol. 24 ›› Issue (6): 467-. doi: 10.3969/j.issn.1005-4979.2014.06.016

CCN2在软骨内成骨过程中作用的研究进展

盛夏涵，蔡协艺

上海交通大学医学院附属第九人民医院口腔颌面外科，上海市口腔医学重点实验室，上海 200011

出版日期:2014-12-28 发布日期:2015-04-02
通讯作者: 蔡协艺，副教授. E-mail:caixieyi27@126.com
作者简介:盛夏涵（1989—），女，浙江人，硕士研究生.
基金资助:
国家自然科学基金（81200766）；上海市科学技术委员会资助项目（13140902702）

Advances on the Role of CCN2 in the Process of Endochondral Ossification

SHENG Xia-han, CAI Xie-yi

Department of Oral and Maxillofacial Surgery, The Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China

Online:2014-12-28 Published:2015-04-02

摘要/Abstract

关键词: CCN2, 软骨内成骨, 软骨细胞, 成骨细胞, 破骨细胞

Key words: CCN2, endochondral ossification, chondrocytes, osteoblasts, osteoclasts

中图分类号:

R782.2

盛夏涵，蔡协艺. CCN2在软骨内成骨过程中作用的研究进展[J]. 《口腔颌面外科杂志》, 2014, 24(6): 467-.

SHENG Xia-han, CAI Xie-yi. Advances on the Role of CCN2 in the Process of Endochondral Ossification[J]. 《Journal of Oral and Maxillofacial Surgery》, 2014, 24(6): 467-.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2014/V24/I6/467

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[3] Yamaai T, Nakanishi T, Asano M, et al. Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development[J]. J Bone Miner Metab, 2005, 23(4): 280-288.

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[5] Nishida T, Kubota S, Nakanishi T, et al. CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes[J]. J Cell Physiol, 2002, 192(1): 55-63.

[6] Maeda A, Nishida T, Aoyama E, et al. CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes [J]. J Biochem, 2009, 145(2): 207-216.

[7] Nishida T, Kubota S, Aoyama E, et al. Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes[J]. Endocrinology, 2011, 152(11): 4232-4241.

[8] Aoyama E, Kubota S, Takigawa M. CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling [J]. FEBS Letters, 2012, 586(24): 4270-4275.

[9] Inoki I, Shiomi T, Hashimoto G, et al. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis[J]. FASEB J, 2002, 16(2): 219-221.

[10] Gao R, Brigstock DR. Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells[J]. Hepatol Res, 2003, 27(3): 214-220.

[11] Mercurio S, Latinkic B, Itasaki N, et al. Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex [J]. Development, 2004, 131(9): 2137-2147.

[12] Kawata K, Kubota S, Eguchi T, et al. Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes[J]. J Cell Sci, 2012, 125(Pt 12):2965-2972.

[13] Nakanishi T, Nishida T, Shimo T, et al. Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture[J]. Endocrinology, 2000, 141(1): 264-273.

[14] Tomita N, Hattori T, Itoh S, et al. Cartilage-specific over-expression of CCN family member 2/Connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth[J]. PloS one, 2013, 8(3):e59226.

[15] Maeda-Uematsu A, Kubota S, Kawaki H, et al. CCN2 as a novel molecule supporting energy metabolism of chondrocytes [J]. J Cell Biochem, 2014, 115(5): 854-865.

[16] Nishida T, Nakanishi T, Asano M, et al. Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro [J]. J Cell Physiol, 2000, 184(2): 197-206.

[17] Mundy C, Gannon M, Popoff SN. Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling[J]. J cellular Physiol, 2014, 229(5): 672-681.

[18] Canalis E, Zanotti S, Smerdel-Ramoya A. Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage [J]. Bone, 2014, 64: 273-280.

[19] Shui C, Riggs BL, Khosla S. The immunosuppressant rapamycin, alone or with transforming growth factor-beta, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligand [J].Calcif Tissue Int, 2002,71(5):437-446.

[20] Nishida T, Emura K, Kubota S, et al. CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP) [J]. J Bone Miner Res, 2011, 26(2): 351-363.

[21] Hu JP, Nishishita K, Sakai E, et al. Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-κB and Akt pathways[J]. Eur J Pharmacol, 2008, 580(1-2): 70-79.

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