破骨细胞细胞膜融合的研究现状

doi:10.3969/j.issn.1005-4979.2022.01.012

《口腔颌面外科杂志》 ›› 2022, Vol. 32 ›› Issue (1): 60-63. doi: 10.3969/j.issn.1005-4979.2022.01.012

破骨细胞细胞膜融合的研究现状

李心照(), 康非吾()

上海牙组织修复与再生工程技术研究中心，同济大学口腔医学院，同济大学附属口腔医院口腔颌面外科，上海 200072

收稿日期:2021-01-24 修回日期:2021-03-14 出版日期:2022-02-28 发布日期:2022-04-25
通讯作者: 康非吾，主任医师. E-mail: kfw@tongji.edu.cn
作者简介:
李心照（1995—），女，内蒙古人，硕士研究生. E-mail: 1330107366@qq.com
基金资助:
国家自然科学基金(81670961)

Research status of osteoclast fusion

LI Xinzhao(), KANG Feiwu()

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai 200072, China

Received:2021-01-24 Revised:2021-03-14 Online:2022-02-28 Published:2022-04-25

摘要/Abstract

摘要：

破骨细胞作为骨代谢过程中唯一一个具有骨吸收功能的细胞，其功能异常会引起骨代谢类疾病。细胞融合是破骨细胞形成过程中的重要过程，对于破骨细胞生物学功能的发挥至关重要。本文通过列举一些在破骨细胞融合过程中的相关因子及其影响因素，阐明其在融合过程中可能的相关分子机制，旨在为治疗破骨细胞相关的骨代谢疾病提供新的治疗靶点。

关键词: 破骨细胞, 细胞融合, 影响因素, 分子机制

Abstract:

Osteoclasts are the only cells with bone resorption function in the process of bone metabolism. Osteoclasts abnormalities will cause bone metabolism diseases. Cell fusion is an important process in the formation of osteoclasts and is essential for the biological functions of osteoclasts. This review listed some related factors and their influencing factors in the process of osteoclast fusion, and clarified the possible related molecular mechanisms, aiming to provide new therapeutic targets for osteoclast-related bone metabolism diseases.

Key words: osteoclasts, cell fusion, influencing factors, molecular mechanism

李心照, 康非吾. 破骨细胞细胞膜融合的研究现状[J]. 《口腔颌面外科杂志》, 2022, 32(1): 60-63.

LI Xinzhao, KANG Feiwu. Research status of osteoclast fusion[J]. 《Journal of Oral and Maxillofacial Surgery》, 2022, 32(1): 60-63.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2022/V32/I1/60

参考文献 19

[1]	杨文杰, 李耀玺, 段莉, 等. 破骨细胞融合分子机制的研究进展[J]. 生物骨科材料与临床研究, 2020, 17(1): 67-70.
[2]	Zeng X, Zhang Y, Wang S, et al. Artesunate suppresses RANKL-induced osteoclastogenesis through inhibition of PLCγ1-Ca²⁺-NFATc1 signaling pathway and prevents ovariectomy-induced bone loss[J]. Biochem Pharmacol, 2017, 124: 57-68. doi: 10.1016/j.bcp.2016.10.007 URL
[3]	Baek JM, Kim JY, Lee CH, et al. Methyl gallate inhibits osteoclast formation and function by suppressing Akt and btk-PLCγ2-Ca²⁺ signaling and prevents lipopolysaccharide-induced bone loss[J]. Int J Mol Sci, 2017, 18(3): E581.
[4]	Tang Y, Zhu J, Huang DQ, et al. Mandibular osteotomy-induced hypoxia enhances osteoclast activation and acid secretion by increasing glycolysis[J]. J Cell Physiol, 2019, 234(7): 11165-11175. doi: 10.1002/jcp.27765 pmid: 30548595
[5]	Huang CM, Yan TL, Xu Z, et al. Hypoxia enhances fusion of oral squamous carcinoma cells and epithelial cells partly via the epithelial-mesenchymal transition of epithelial cells[J]. Biomed Res Int, 2018, 2018: 5015203.
[6]	Shanmugarajan S, Zhang Y, Moreno-Villanueva M, et al. Combined effects of simulated microgravity and radiation exposure on osteoclast cell fusion[J]. Int J Mol Sci, 2017, 18(11): E2443.
[7]	许娟, 朱月松, 亓文波. 高糖对RANKL诱导的破骨细胞分化过程中c-fos和NFATc1表达水平的影响[J]. 中华临床医师杂志(电子版), 2016, 10(16): 2438-2441.
[8]	Arioka M, Takahashi-Yanaga F, Tatsumoto N, et al. Inorganic phosphate-induced impairment of osteoclast cell-cell fusion by the inhibition of AP-1-mediated DC-STAMP expression[J]. Biochem Biophys Res Commun, 2017, 493(1): 9-13. doi: 10.1016/j.bbrc.2017.09.096 URL
[9]	Weiler J, Dittmar T. Minocycline impairs TNF-α-induced cell fusion of M13SV1-Cre cells with MDA-MB-435-pFDR1 cells by suppressing NF-κB transcriptional activity and its induction of target-gene expression of fusion-relevant factors[J]. Cell Commun Signal, 2019, 17(1): 71. doi: 10.1186/s12964-019-0384-9 pmid: 31266502
[10]	Chiu YH, Ritchlin CT. DC-STAMP: A key regulator in osteoclast differentiation[J]. J Cell Physiol, 2016, 231(11): 2402-2407. doi: 10.1002/jcp.25389 URL
[11]	Chiu YH, Schwarz E, Li DG, et al. Dendritic cell-specific transmembrane protein (DC-STAMP) regulates osteoclast differentiation via the Ca²⁺/NFATc1 axis[J]. J Cell Physiol, 2017, 232(9): 2538-2549. doi: 10.1002/jcp.v232.9 URL
[12]	Witwicka H, Hwang SY, Reyes-Gutierrez P, et al. Studies of OC-STAMP in osteoclast fusion: A new knockout mouse model, rescue of cell fusion, and transmembrane topology[J]. PLoS One, 2015, 10(6): e0128275. doi: 10.1371/journal.pone.0128275 URL
[13]	Murata Y, Kotani T, Ohnishi H, et al. The CD47-SIRPα signalling system: Its physiological roles and therapeutic application[J]. J Biochem, 2014, 155(6): 335-344. doi: 10.1093/jb/mvu017 pmid: 24627525
[14]	Suzuki K, Zhu B, Rittling SR, et al. Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts[J]. J Bone Miner Res, 2002, 17(8): 1486-1497. doi: 10.1359/jbmr.2002.17.8.1486 pmid: 12162503
[15]	Lee SH, Rho J, Jeong D, et al. V-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation[J]. Nat Med, 2006, 12(12): 1403-1409. doi: 10.1038/nm1514
[16]	Møller AM, Delaissé JM, Søe K. Osteoclast fusion: Time-lapse reveals involvement of CD47 and syncytin-1 at different stages of nuclearity[J]. J Cell Physiol, 2017, 232(6): 1396-1403. doi: 10.1002/jcp.25633 pmid: 27714815
[17]	Agrawal A, Gartland A. P2X7 receptors: Role in bone cell formation and function[J]. J Mol Endocrinol, 2015, 54(2): R75-R88. doi: 10.1530/JME-14-0226 URL
[18]	Jordan LA, Erlandsson MC, Fenner BF, et al. Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis[J]. Rheumatology (Oxford), 2018, 57(11): 2042-2052. doi: 10.1093/rheumatology/key196 pmid: 30053130
[19]	Miyauchi Y, Ninomiya K, Miyamoto H, et al. The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis[J]. J Exp Med, 2010, 207(4): 751-762. doi: 10.1084/jem.20091957 URL

选择文件类型/文献管理软件名称

选择包含的内容

破骨细胞细胞膜融合的研究现状

Research status of osteoclast fusion

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献 19

相关文章 15

编辑推荐

Metrics

本文评价

[1]	孙斌, 王佐林. 自噬在骨代谢中作用的研究进展[J]. 《口腔颌面外科杂志》, 2023, 33(4): 263-265.
[2]	杨毅璇, 羊正林, 杨森, 郭丽娟. 颏部软组织黏液瘤1例并文献复习[J]. 《口腔颌面外科杂志》, 2023, 33(3): 198-201.
[3]	别苗苗, 唐燚, 康非吾. HIF-1α介导破骨细胞对小鼠髁突软骨发育的影响[J]. 《口腔颌面外科杂志》, 2022, 32(4): 203-208.
[4]	李琴，王佐林. TREM-2/DAP12复合物在牙周炎中的作用及研究进展[J]. 《口腔颌面外科杂志》, 2021, 31(2): 110-.
[5]	丁云波，姚小武，陈仕生，卢子正，林敏校，桂心伟. 下颌骨大型囊性病变开窗术后骨腔改变及其影响因素[J]. 《口腔颌面外科杂志》, 2020, 30(2): 85-.
[6]	裴庆国,王佐林. 髓样细胞表达触发受体?鄄2调控破骨细胞分化的研究进展[J]. 《口腔颌面外科杂志》, 2019, 29(6): 352-.
[7]	王雅冰，苏俭生. 川陈皮素纳米粒对破骨细胞作用的实验研究[J]. 《口腔颌面外科杂志》, 2019, 29(1): 11-16.
[8]	袁历峰，王佐林. CXC-型趋化因子4对单核巨噬细胞破骨向分化影响的实验研究[J]. 《口腔颌面外科杂志》, 2018, 28(6): 301-308.
[9]	李傲楠1,2，顾客1,2，文勇1,2. EGCG对口腔癌细胞的作用及其分子机制研究进展[J]. 《口腔颌面外科杂志》, 2018, 28(3): 172-175.
[10]	万会璇，蔡明详，孙瑶. 局部激活破骨细胞对大鼠应用双膦酸盐后拔牙创愈合的影响[J]. 《口腔颌面外科杂志》, 2018, 28(2): 65-.
[11]	陈静雯1,2 （综述），杨旭东1 （审校）. 上颌骨缺损对生存质量影响的研究进展[J]. 《口腔颌面外科杂志》, 2017, 27(6): 422-.
[12]	邬琪1, 冷颖1, 段昌华1, 周子亮1, 彭助力2. 二甲双胍对于人口腔鳞癌SCC-4和CAL-27细胞株的抑制作用[J]. 《口腔颌面外科杂志》, 2017, 27(4): 246-251.
[13]	黄丹青，康非吾，周小康，吴情，纪映辰，王伟伟，马嘉磊. 下颌截骨术对兔颌骨非术区骨改建的影响[J]. 《口腔颌面外科杂志》, 2016, 26(2): 83-87.
[14]	华洪飞1，王宁涛1，张文杰2，张伟杰1，张志愿1，王绍义1. 双膦酸盐致颌骨坏死的大鼠模型研究[J]. 《口腔颌面外科杂志》, 2016, 26(1): 19-24.
[15]	刘向辉，张磊，黄辉，张静东，张林，沈彬. 上颌即刻种植后牙槽骨改建的CBCT分析[J]. 《口腔颌面外科杂志》, 2015, 25(4): 280-283.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

破骨细胞细胞膜融合的研究现状

Research status of osteoclast fusion

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献 19

相关文章 15

编辑推荐

Metrics

本文评价