[1] Wang L, Zou DH, Zhang S. Repair of bone defects around dental implants with bone morphogenetic protein/fibroblast growth factor-loaded porous calcium phosphate cement: a pilot study in a canine model [J]. Clin Oral Implants Res, 2011, 22(2): 173-181.
[2] Otto WR, Rao J. Tomorrow's skeleton staff: mesenchymal stem cells and the repair of bone and cartilage [J]. Cell Prolif, 2004, 37(1): 97-110.
[3] Xu HH, Quinn JB, Takagi S, et al. Synergistic reinforcement of in situ hardening calcium phosphate composite scaffold for bone tissue engineering [J]. Biomaterials, 2004, 25(6):1029-1037.
[4] Cowan CM, Shi YY, Aalami OO, et al. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects [J]. Nat Biotechnol, 2004,22(5): 560-567.
[5] Lieberman JR, Daluiski A, Einhorn TA. The role of growth factors in the repair of bone-Biology and clinical applications [J]. J Bone Joint Surg Am,2002, 84-A(6): 1032-1044.
[6] Bridwell KH, Anderson PA, Boden SD, et al. What's new in spine surgery [J]. J Bone Joint Surg, Am, 2004, 86-A(7): 1587-1596.
[7] Geesink RG, Hoefnagels NH, Bulstra SK. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect [J]. J Bone Joint Surg Br, 1999, 81 (4): 710-718.
[8] Zhao B, Katagiri T, Toyoda H, et al. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2 [J]. J Biol Chem, 2006, 281(32): 23246-23253.
[9] Zhao J, Ohba S, Shinkai M, et al. Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner [J]. Biochem Biophys Res Commun, 2008, 369(2): 444-448.
[10] Zhao J Ohba S, Komiyama Y, et al. Icariin: a potential osteoinductive compound for bone tissue engineering [J]. Tissue Eng Part A, 2010, 16(1): 233-243.
[11] Nian H, Ma MH, Nian SS, et al. Antiosteoporotic activity of icariin in ovariectomized rats [J]. Phytomedicine, 2009, 16(4): 320-326.
[12] Hsieh TP, Sheu SY, Sun JS, et al. Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression [J]. Phytomedicine, 2010, 17(6): 414-423.
[13] Ma HP, Ming LG, Ge BF, et al. Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro[J]. J Cell Biochem, 2011,112(3): 916-923.
[14] Qian Q, Li SL, Sun E, et al. Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry [J]. J Pharm Biomed Anal, 2012, 66: 392-398.
[15] Chen KM, Ge BF,Ma HP, et al. Icariin, a flavonoid from the herb Eimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells [J]. Pharmazie, 2005, 60(12): 939-942.
[16] Huang J, Yuan L, Wang X, et al. Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro [J]. Life Sci, 2007, 81(10): 832-840.
[17] Fan JJ, Cao LG, Wu T, et al. The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells [J]. Molecules, 2011, 16(12): 10123-10133.
[18] 郑洪军,吕振华,胡有谷,等. 淫羊藿对体外培养破骨细胞的影响[J]. 中华实验外科杂志, 2000, 17(5): 460-461.
[19] Mok SK, Chen WF, Lai WP, et al. Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functionsin UMR 106 cells [J]. Br J Pharmacol, 2010, 159 (4): 939-949.
[20] 李华珠,黄文秀,杜志斌,等. 淫羊藿对骨质疏松大鼠骨代谢影响的实验研究[J]. 口腔颌面外科杂志, 2010, 20(2):136-140.
[21] Wei H, Zili L, Yuanlu C, et al. Effect of icariin on bone formation during distraction osteogenesis in the rabbit mandible [J]. Int J Oral Maxillofac Surg, 2011, 40(4): 413-418.
[22] Wang F, Liu Z, Lin S, et al. Icariin enhances the healing of rapid palatal expansion induced root resorption in rats [J]. Phytomedicine, 2012, 19(11): 1035-1041.
[23] Liang W, Lin M, Li X, et al. Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line [J]. Int J Mol Med, 2012, 30(4): 889-895.
[24] Zheng D, Peng S, Yang SH, et al. The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient mice [J]. Bone, 2012, 51(1): 85-92.
[25] Hsieh TP, Sheu SY, Sun JS, et al. Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE2 synthesis [J]. Phytomedicine, 2011,18(2-3): 176-185.
[26] Zhang X, Guo Y, Li DX, et al. The effect of loading icariin on biocompatibility and bioactivity of porous β-TCP ceramic [J]. J Mater Sci Mater Med, 2011, 22(2): 371-379.
[27] Wu T, Nan KH,Chen JD, et al. A new bone repair scaffold combined with chitosan/hydroxyapatite and sustained releasing icariin [J]. Chin Sci Bull, 2009, 54(17): 2953-2961.
[28] Fan J, Bi L, Wu T, et al. A combined chitosan/nano-size hydroxyapatite system for the controlled release of icariin [J]. J Mater Sci Mater Med, 2012, 23(2): 399-407.
[29] Yang W, Yu XC, Chen XY, et al. Pharmacokinetics and tissue distribution profile of icariin propylene glycol-liposome intraperitoneal injection in mice [J]. J Pharm Pharmacol, 2012. 64(2): 190-198.
[30] Zhang G, Qin L, Shi Y.Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial [J]. J Bone Miner Res, 2007, 22(7): 1072-1079.
[31] 曾炎辉. 淫羊藿治疗绝经后骨质疏松症50例[J]. 陕西中医,2005,26(5):405-406. |