Functions of lncRNA in the osteogenic differentiation of periodontal ligament stem cells

doi:10.12439/kqhm.1005-4979.2024.03.010

Abstract

Abstract:

Stem cells derived from dental tissues are endemic in oral areas and they are of great significance to the regeneration of alveolar bone and the reconstruction of alveolar bone. Long non-coding RNA (lncRNA) was found to be involved in regulating osteogenic differentiation of stem cells derived from tooth-related tissues. In this review, we review the latest research progress on the role, regulatory targets and specific mechanisms of lncRNA in the osteogenic differentiation of tooth-related tissue-derived stem cells.

Key words: long non-coding RNA, periodontal ligament stem cells, osteogenesis differentiation

摘要：

来源于牙相关组织的干细胞是口腔范围内特有的干细胞，对牙槽骨丢失后的再生或修复及牙槽骨的改建等具有重要意义。长链非编码RNA（long non-coding RNA，lncRNA）被发现参与牙相关组织干细胞的成骨向分化。本文就lncRNA在牙相关组织来源干细胞成骨分化过程中发挥的作用、调控的靶点及具体机制的最新研究进展进行综述。

关键词: 长链非编码RNA, 牙周膜干细胞, 成骨分化

CLC Number:

R782

CAO Bangping, SU Jiansheng. Functions of lncRNA in the osteogenic differentiation of periodontal ligament stem cells[J]. 《Journal of Oral and Maxillofacial Surgery》, 2024, 34(3): 227-230.

曹帮萍, 苏俭生. LncRNA在牙周膜干细胞成骨分化中的作用[J]. 《口腔颌面外科杂志》, 2024, 34(3): 227-230.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2024.03.010

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2024/V34/I3/227

References 35

[1]	McGovern JA, Griffin M, Hutmacher DW. Animal models for bone tissue engineering and modelling disease[J]. Dis Model Mech, 2018, 11(4): dmm033084.
[2]	叶青松, 王晓燕. 牙源性干细胞储存和临床应用的研究进展[J]. 口腔疾病防治, 2018, 26(1): 15-25. doi: 10.12016/j.issn.2096-1456.2018.01.004
[3]	Sharpe PT. Dental mesenchymal stem cells[J]. Development, 2016, 143(13): 2273-2280. doi: 10.1242/dev.134189 pmid: 27381225
[4]	周洁, 王颖, 张雷, 等. 牙源性干细胞的特点及其在骨组织工程中的应用[J]. 国际口腔医学杂志, 2018, 45(3): 280-285.
[5]	Stanko P, Kaiserova K, Altanerova V, et al. Comparison of human mesenchymal stem cells derived from dental pulp, bone marrow, adipose tissue, and umbilical cord tissue by gene expression[J]. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2014, 158(3): 373-377. doi: 10.5507/bp.2013.078 pmid: 24145770
[6]	Jarroux J, Morillon A, Pinskaya M. History, discovery, and classification of lncRNAs[J]. Adv Exp Med Biol, 2017, 1008: 1-46. doi: 10.1007/978-981-10-5203-3_1 pmid: 28815535
[7]	Zhang XP, Wang W, Zhu WD, et al. Mechanisms and functions of long non-coding RNAs at multiple regulatory levels[J]. Int J Mol Sci, 2019, 20(22): 5573.
[8]	Chen DR, Wu LP, Liu L, et al. Comparison of HIF1A-AS1 and HIF1A-AS2 in regulating HIF-1α and the osteogenic differentiation of PDLCs under hypoxia[J]. Int J Mol Med, 2017, 40(5): 1529-1536.
[9]	Zhang ZJ, He Q, Yang SY, et al. Mechanical force-sensitive lncRNA SNHG8 inhibits osteogenic differentiation by regulating EZH2 in hPDLSCs[J]. Cell Signal, 2022, 93: 110285.
[10]	Guo JB, Zheng MQ. The regulation mechanism of LINC00707 on the osteogenic differentiation of human periodontal ligament stem cells[J]. J Mol Histol, 2022, 53(1): 13-26.
[11]	Xiang J, Bian Y. PWAR6 interacts with miR-106a-5p to regulate the osteogenic differentiation of human periodontal ligament stem cells[J]. Mol Med Rep, 2021, 23(4): 268.
[12]	Zheng YF, Li XB, Huang YP, et al. Time series clustering of mRNA and lncRNA expression during osteogenic differentiation of periodontal ligament stem cells[J]. PeerJ, 2018, 6: e5214.
[13]	Qu Q, Fang FC, Wu BL, et al. Potential role of long non-coding RNA in osteogenic differentiation of human periodontal ligament stem cells[J]. J Periodontol, 2016, 87(7): e127-e137.
[14]	Liu ZJ, Xu SM, Dao JF, et al. Differential expression of lncRNA/miRNA/mRNA and their related functional networks during the osteogenic/odontogenic differentiation of dental pulp stem cells[J]. J Cell Physiol, 2020, 235(4): 3350-3361. doi: 10.1002/jcp.29223 pmid: 31549394
[15]	Wang Z, Huang YL, Tan LJ. Downregulation of lncRNA dancr promotes osteogenic differentiation of periodontal ligament stem cells[J]. BMC Dev Biol, 2020, 20(1): 2. doi: 10.1186/s12861-019-0206-8 pmid: 31931700
[16]	Wu XX, Sui ZL, Zhang HD, et al. Integrated analysis of lncRNA-mediated ceRNA network in lung adenocarcinoma[J]. Front Oncol, 2020, 10: 554759.
[17]	Liao CH, Zhou YT, Li MF, et al. LINC00968 promotes osteogenic differentiation in vitro and bone formation in vivo via regulation of miR-3658/RUNX2[J]. Differentiation, 2020, 116: 1-8. doi: 10.1016/j.diff.2020.09.005 pmid: 33065511
[18]	Liu Y, Zeng XM, Miao J, et al. Upregulation of long noncoding RNA MEG3 inhibits the osteogenic differentiation of periodontal ligament cells[J]. J Cell Physiol, 2019, 234(4): 4617-4626. doi: 10.1002/jcp.27248 pmid: 30256394
[19]	Huang YP, Han YN, Guo RZ, et al. Long non-coding RNA FER1L4 promotes osteogenic differentiation of human periodontal ligament stromal cells via miR-874-3p and vascular endothelial growth factor A[J]. Stem Cell Res Ther, 2020, 11(1): 5. doi: 10.1186/s13287-019-1519-z pmid: 31900200
[20]	Wang L, Wu F, Song Y, et al. Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients[J]. Cell Death Dis, 2016, 7(8): e2327.
[21]	Li L, Ge JP. Exosome-derived lncRNA-Ankrd26 promotes dental pulp restoration by regulating miR-150-TLR4 signaling[J]. Mol Med Rep, 2022, 25(5): 152.
[22]	Jia Q, Chen XL, Jiang WK, et al. The regulatory effects of long noncoding RNA-ANCR on dental tissue-derived stem cells[J]. Stem Cells Int, 2016, 2016: 3146805.
[23]	Wu D, Yin L, Sun DG, et al. Long noncoding RNA TUG1 promotes osteogenic differentiation of human periodontal ligament stem cell through sponging microRNA-222-3p to negatively regulate Smad2/7[J]. Arch Oral Biol, 2020, 117: 104814.
[24]	Jia B, Qiu XL, Chen J, et al. A feed-forward regulatory network lncPCAT1/miR-106a-5p/E2F5 regulates the osteogenic differentiation of periodontal ligament stem cells[J]. J Cell Physiol, 2019, 234(11): 19523-19538. doi: 10.1002/jcp.28550 pmid: 30997692
[25]	庞鸣, 韦红霞, 陈茜. 长链非编码RNA钾离子电压门控通道亚家族Q成员1重叠转录本1通过靶向miR-24-3p调控人牙周膜干细胞增殖和成骨分化[J]. 华西口腔医学杂志, 2021, 39(5): 547-554.
[26]	Li ZB, Guo XJ, Wu SN. Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation[J]. Stem Cell Res Ther, 2020, 11(1): 435. doi: 10.1186/s13287-020-01953-8 pmid: 33028420
[27]	Xu YR, Qin W, Guo DH, et al. LncRNA-TWIST1 promoted osteogenic differentiation both in PPDLSCs and in HPDLSCs by inhibiting TWIST1 expression[J]. Biomed Res Int, 2019, 2019: 8735952.
[28]	Chen ZY, Zheng JX, Hong H, et al. lncRNA HOTAIRM1 promotes osteogenesis of hDFSCs by epigenetically regulating HOXA2 via DNMT1 in vitro[J]. J Cell Physiol, 2020, 235(11): 8507-8519. doi: 10.1002/jcp.29695 pmid: 32324272
[29]	Yang QL, Han YN, Liu P, et al. Long noncoding RNA GAS5 promotes osteogenic differentiation of human periodontal ligament stem cells by regulating GDF5 and p38/JNK signaling pathway[J]. Front Pharmacol, 2020, 11: 701. doi: 10.3389/fphar.2020.00701 pmid: 32508644
[30]	He Q, Yang SY, Gu XG, et al. Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A[J]. Cell Death Dis, 2018, 9(5): 455. doi: 10.1038/s41419-018-0484-2 pmid: 29674645
[31]	Jia Q, Jiang WK, Ni LX. Down-regulated non-coding RNA (lncRNA-ANCR) promotes osteogenic differentiation of periodontal ligament stem cells[J]. Arch Oral Biol, 2015, 60(2): 234-241. doi: 10.1016/j.archoralbio.2014.10.007 pmid: 25463901
[32]	Deng LD, Hong H, Zhang XQ, et al. Down-regulated lncRNA MEG3 promotes osteogenic differentiation of human dental follicle stem cells by epigenetically regulating Wnt pathway[J]. Biochem Biophys Res Commun, 2018, 503(3): 2061-2067.
[33]	Qin QY, Yang HQ, Zhang C, et al. lncRNA HHIP-AS1 promotes the osteogenic differentiation potential and inhibits the migration ability of periodontal ligament stem cells[J]. Stem Cells Int, 2021, 2021: 5595580.
[34]	Liu YD, Liu QF, Li ZP, et al. Long non-coding RNA and mRNA expression profiles in peri-implantitis vs periodontitis[J]. J Periodontal Res, 2020, 55(3): 342-353. doi: 10.1111/jre.12718 pmid: 31853997
[35]	Zou YG, Li C, Shu FP, et al. lncRNA expression signatures in periodontitis revealed by microarray: The potential role of lncRNAs in periodontitis pathogenesis[J]. J Cell Biochem, 2015, 116(4): 640-647. doi: 10.1002/jcb.25015 pmid: 25399840

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