Abstract:

With the continuous explorations and researches of osteocytes, osteocytes are no longer mistaken for a kind of quiescent and passive cells, but active and positive cells, which play important regulatory roles in osteoblasts and osteoclasts. While an increasing number of studies have identified key signaling pathways and crosstalk mechanisms related to osteocytes. To some extent, the role of osteocyte apoptosis and its complex mechanisms occurring in various states of pathologies are still not elucidated. If further studies can be performed, this will help to fully understand the function and mechanism of osteocytes in a variety of states, as well as provide a novel target for bone diseases. At present, there are many reports about osteocytes regulating osteoblasts and osteoclasts. In this paper, the research progresses in regulation and mechanism of osteoblasts and osteoclasts by osteocytes are reviewed.

Key words: osteocyte, osteoblast, osteoclast, sclerostin, pulsating fluid flow, apoptosis

摘要：

随着人们对骨细胞探索和研究的不断深入，骨细胞不再被人们误认为是静止的、被动的细胞，而是一种活跃的、主动的细胞，并且对成骨细胞和破骨细胞有重要的调控作用。尽管越来越多的研究已经在一定程度上确定了骨细胞相关的关键信号通路和串扰机制，但是在各种病理状态下发生的骨细胞凋亡的作用及其复杂机制仍未被阐明。如果能进行更深入的研究，那将有助于充分了解不同状态下骨细胞的作用及机制，并为骨骼疾病的治疗提供新的靶点。目前已有骨细胞调控成骨细胞和破骨细胞的相关报道，本文就骨细胞对成骨细胞和破骨细胞的调控及机制的研究进展作一综述。

关键词: 骨细胞, 成骨细胞, 破骨细胞, 骨硬化蛋白, 脉动流, 凋亡

CLC Number: 

• R782