Research advances in skeletal stem cells

doi:10.12439/kqhm.1005-4979.2025.03.008

Abstract

Abstract:

The development, homeostasis maintenance, and damage repair of the skeletal system require continuous proliferation and differentiation of stem and progenitor cells. Although studies on bone marrow mesenchymal stem cells (BMSCs) have accumulated substantial evidence over the past decades, the definition and markers of skeletal stem cells (SSCs) remain controversial. Recent advances in lineage tracing and bioinformatics technologies have facilitated the purification and functional investigation of SSCs. This review systematically summarizes different SSC populations based on their origins and markers, as well as their functions in skeletal development and repair.

Key words: skeletal stem cells, bone marrow mesenchymal stem cells, bone repair, bone development

摘要：

骨骼系统的生长发育、稳态维持和损伤修复依赖于骨干祖细胞的持续增殖和分化。尽管骨髓间充质干细胞（bone marrow mesenchymal stem cells，BMSCs）的研究在过去的几十年中已积累较多进展，但是骨骼干细胞（skeletal stem cells，SSCs）的定义和标志物仍然存在争议。近年来，谱系示踪和生物信息学相关技术的进步，推动了SSCs的纯化分离和功能研究。本文系统综述了不同来源和标志物的SSCs类群及其在骨骼发育和修复中的功能。

关键词: 骨骼干细胞, 骨髓间充质干细胞, 骨修复, 骨发育

CLC Number:

R782

CHEN Xiaofan, WANG Zuolin. Research advances in skeletal stem cells[J]. 《Journal of Oral and Maxillofacial Surgery》, 2025, 35(3): 219-222.

陈晓帆, 王佐林. 骨骼干细胞的研究进展[J]. 《口腔颌面外科杂志》, 2025, 35(3): 219-222.

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URL: https://journal06.magtech.org.cn/Jweb_joms/EN/10.12439/kqhm.1005-4979.2025.03.008

https://journal06.magtech.org.cn/Jweb_joms/EN/Y2025/V35/I3/219

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