[1] Peter LI, Withers HR. Applying radiobiological principles to combined modality treatment of head and neck cancer-the time factor[J]. Int J Radiat Oncol Biol Phys, 1997,39(4):831-836.
[2] 沈春英,胡超苏,何少琴. 头颈部恶性肿瘤放射治疗后唾液腺功能减退的防治[J]. 中华放射肿瘤杂志,2003,12（增）:62-64.
[3] Vissink A,Mitchell JB,Baum BJ,et al. Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers[J]. Int J Radiat Oncol Biol Phys,2010,78(4):983-991.
[4] Eriksson D, Stigbrand T. Radiation-induced cell death mechanisms[J]. Tumour Biol,2010,31(4):363-372.
[5] Gresik EW. The granular convoluted tubule (GCT) cell of rodent submandibular glands[J]. Microsc Res Tech,1994,27(1):1-24.
[6] Denny PC, Ball WD, Redman RS. Salivary glands: a paradigm for diversity of gland development[J]. Crit Rev Oral Biol Med,1997,8(1):51-75.
[7] Grundmann O, Mitchell GC, Limesand KH. Sensitivity of salivary glands to radiation: from animal models to therapies[J]. J Dent Res,2009,88(10):894-903.
[8] Tatsuishi Y, Hiyota M, Kishi T, et al. Human salivary gland stem/progenitor cells remain dormant even after irradiation[J]. Int J Mol Med,2009,24(3):361-366.
[9] Coppes RP, Meter A, Latumalea SP, et al. Defects in muscarinic receptor-coupled signal transduction in isolated parotid gland cells after in vivo irradiation: evidence for a non-DNA target of radiation[J]. Br J Cancer,2005,92(3):539-546.
[10] Eneroth CM, Henrikson CO, Jakobsson PA. Pre-irradiationqualities of a parotid gland predicting the grade of functional disturbance by radiotherapy[J]. Acta Otolaryngol,1972,74(6):436-444.
[11] Roesink JM, Moerland MA, Battermann JJ, et al. Quantitative dose-volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region[J]. Int J Radiat Oncol Biol Phys,2001,51(4):938-946.
[12] Jensen SB, Pedersen AM, Vissink A, et al. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life[J]. Support Care Cancer,2010,18(8):1039-1060.
[13] Smith S, Neaves W, Teitelbaum S. Adult stem cell treatments for diseases[J]? Science,2006,313(5786):439.
[14] Barka T, Van der Noen H. Dissociation of rat parotid gland[J]. Lab Invest,1975,32(3):373-380.
[15] McCombe P, Lavin M, Kidson C. Control of DNA repair linked to neuroblastoma differentiation[J]. Int J Radiat Biol Relat Stud Phys Chem Med,1976,29(6):523-531.
[16] Hisatomi Y, Okumura K, Nakamura K, et al. Flow cytometric isolation of endodermal progenitors from mouse salivary gland differentiate into hepatic and pancreatic lineages[J]. Hepatology,2004,39(3):667-675.
[17] Shay JW, Wright WE. Telomeres and telomerase in normal and cancer stem cells[J]. FEBS Lett,2010,584(17):3819-3825.
[18] Flores I, Blasco MA. The role of telomeres and telomerase in stem cell aging[J]. FEBS Lett,2010,584(17):3826-3830.
[19] Gil J, Stembalska A, Pesz KA, et al. Cancer stem cells: the theory and perspectives in cancer therapy[J]. J Appl Genet,2008,49(2):193-199.
[20] Berdasco M, Esteller M. Aberrant epigenetic landscape in cancer: how cellular identity goes awry[J]. Dev Cell,2010,19(5):698-711.
[21] Gorjup E, Danner S, Rotter N, et al. Glandular tissue from human pancreas and salivary gland yields similar stem cell populations[J]. Eur J Cell Biol,2009,88(7):409-421.
[22] Frosina G. The bright and the dark sides of DNA repair in stem cells[J]. J Biomed Biotechnol,2010,2010:845396.
[23] Zeilstra LJ, Vissink A, Konings AW, et al. Radiation induced cell loss in rat submandibular gland and its relation to gland function[J]. Int J Radiat Biol,2000,76(3):419-429.
[24] Coppes RP, van der Goot A, Lombaert IM. Stem cell therapy to reduce radiation-induced normal tissue damage[J]. Semin Radiat Oncol,2009,19(2):112-121.
[25] Stephens LC, Ang KK, Schultheiss TE, et al. Target cell and mode of radiation injury in rhesus salivary glands[J]. Radiother Oncol,1986,7(2):165-174.
[26] Stephens LC, Schultheiss TE, Price RE, et al. Radiation apoptosis of serous acinar cells of salivary and lacrimal glands[J]. Cancer,1991,67(6):1539-1543.
[27] Konings AW, Coppes RP, Vissink A. On the mechanism of salivary gland radiosensitivity[J]. Int J Radiat Oncol Biol Phys,2005,62(4):1187-1194.
[28] Coppes RP, Vissink A, Konings AW. Comparison of radiosensitivity of rat parotid and submandibular glands after different radiation schedules[J]. Radiother Oncol,2002,63(3):321-328.
[29] Braam PM, Roesink JM, Moerland MA,et al. Long-term parotid gland function after radiotherapy[J]. Int J Radiat Oncol Biol Phys,2005,62(3):659-664.
[30] Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium[J]. Nature,2001,410(6829):701-705.
[31] Limesand KH, Said S, Anderson SM. Suppression of radiation-induced salivary gland dysfunction by IGF-1[J]. PLoS One,2009,4(3):e4663.
[32] Thula TT, Schultz G, Tran-Son-Tay R, et al. Effects of EGF and bFGF on irradiated parotid glands[J]. Ann Biomed Eng,2005,33(5):685-695.
[33] Lombaert IM, Brunsting JF, Wierenga PK, et al. Keratinocyte growth factor prevents radiation damage to salivary glands by expansion of the stem/progenitor pool[J]. Stem Cells,2008,26(10):2595-2601.
[34] Cotrim AP, Sowers A, Mitchell JB, et al. Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands[J]. Mol Ther,2007,15(12):2101-2106.
[35] Burlage FR, Roesink JM, Kampinga HH, et al. Protection of salivary function by concomitant pilocarpine during radiotherapy: a double-blind, randomized, placebo-controlled study[J]. Int J Radiat Oncol Biol Phys,2008,70(1):14-22.
[36] Collins CA, Olsen I, Zammit PS, et al. Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche[J]. Cell,2005,122(2):289-301.
[37] Dawn B, Stein AB, Urbanek K, et al. Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function[J]. Proc Natl Acad Sci U S A,2005,102(10):3766-3771.
[38] Lombaert IM, Brunsting JF, Wierenga PK, et al. Rescue of salivary gland function after stem cell transplantation in irradiated glands[J]. PLoS One,2008,3(4):e2063. |