种植体周龈沟液高迁移率族蛋白B1的检测分析

doi:10.3969/j.issn.1005-4979.2012.05.011

《口腔颌面外科杂志》 ›› 2012, Vol. 22 ›› Issue (5): 354-354. doi: 10.3969/j.issn.1005-4979.2012.05.011

种植体周龈沟液高迁移率族蛋白B1的检测分析

刘金盼¹ , 王明国² , 李静¹ , 杨世茂³

1．潍坊医学院口腔医学院，山东潍坊 261053；2．济南市中心医院口腔科，山东济南 250013；3．山东大学口腔医学院，山东济南 250012

出版日期:2012-10-28 发布日期:2013-01-02
通讯作者: 王明国，副教授. E-mail：wmgsh@163.com
作者简介:刘金盼（1983—），男，山东聊城人，硕士研究生. E-mail：kingpanlau@gmail.com

Expression of High Mobility Group Box 1 Levels in Crevicular Fluid of Peri-implantitis Tissues

LIU Jin-pan¹, WANG Ming-guo², LI Jing¹, YANG Shi-mao³

1.School of Stomatology, Weifang Medical College, Weifang 261053; 2. Department of Stomatology, Jinan Municipal Central Hospital, Jinan 250013; 3.College of Stomatology, Shandong University, Jinan 250012, Shandong Province, China

Online:2012-10-28 Published:2013-01-02

摘要/Abstract

摘要： 目的：检测种植体周围炎患者龈沟液(gingival crevicular fluid, GCF)中高迁移率族蛋白B-1 (high mobility group box l, HMGB-1)的水平，以探讨HMGB-1水平与种植体周围炎间的关系。方法：经患者知情同意，选取行种植手术1年以上的健康种植体39颗和种植体周围炎40颗，共79颗种植体，收集种植体周围GCF，并运用ELISA法检测其中HMGB-1、IL-1β、IL-8、TNF-α的浓度，同时检测种植体周围的临床指标。结果：轻度种植体周围炎组的HMGB-1、IL-1β、IL-8及TNF-α浓度高于健康种植体组，重度种植体周围炎的浓度水平又高于轻度种植体周围炎组，HMGB-1与IL-1β、TNF-α的浓度之间亦存在正相关关系（P<0.01）。结论：种植体周围GCF中HMGB-1水平变化与种植体周围炎的病变程度有关，且与经典炎症因子间存在显著相关性，临床检测GCF中HMGB-1水平可作为诊断种植体周围炎的客观指标。

关键词: 高迁移率族蛋白B-1, 炎症因子, 相关性, 种植体周围炎

Abstract: Objective：To analyze whether the expression of high mobility group box 1 protein (HMGB-1) in gingival crevicular fluid (GCF) are associated with the severity of peri-implantitis. Methods：GCF was sampled from 79 implantation patients including 39 normal peri-implant tissue and 40 peri-implantitis tissues. HMGB-1，IL-1β，IL-8，and TNF-α levels were analyzed using ABC-ELISA. Clinical parameters were measured to investigate their relationships. Statistical analyses were performed with SPSS 13.0 software. Results：Significant difference of HMGB-1 expression was observed between healthy implant sites and peri-implantitis sites (P<0.01). The expression levels of HMGB-1 showed positive correlation with those of IL-1β，IL-8, and TNF-α. Conclusion: HMGB-1 cytokine in GCF may be of value as a parameter in diagnosis and prognosis for peri-implantitis.

Key words: correlation coefficient, cytokine, HMGB-1, peri-implantitis

中图分类号:

R782.13

刘金盼 , 王明国 , 李静 , 杨世茂. 种植体周龈沟液高迁移率族蛋白B1的检测分析[J]. 《口腔颌面外科杂志》, 2012, 22(5): 354-354.

LIU Jin-pan, WANG Ming-guo, LI Jing, YANG Shi-mao. Expression of High Mobility Group Box 1 Levels in Crevicular Fluid of Peri-implantitis Tissues[J]. 《Journal of Oral and Maxillofacial Surgery》, 2012, 22(5): 354-354.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2012/V22/I5/354

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Expression of High Mobility Group Box 1 Levels in Crevicular Fluid of Peri-implantitis Tissues

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