摘要： 泛素化修饰是机体一种非常重要的蛋白质翻译后修饰方式，其广泛参与细胞周期、DNA修复、信号转导、转录调控等生物学过程。近些年，蛋白质泛素化修饰在恶性肿瘤发生和发展中的作用，受到国内外广泛关注。尤其是E3泛素连接酶，它能特异性识别作用底物，泛素化修饰的特异性就取决于该连接酶。研究表明，E3泛素连接酶功能异常与恶性肿瘤等多种疾病的病理过程密切相关，因此分析特定的E3连接酶在恶性肿瘤中的作用和机制，有助于加深对恶性肿瘤发生、发展过程中分子机制的认识，为恶性肿瘤相关分子分类和治疗靶点提供实验基础。本文对E3泛素连接酶CHIP的功能，尤其与上皮性癌关系的研究进展进行综述。

关键词: E3泛素连接酶, 热休克蛋白70碳末端相互作用蛋白（CHIP）, 上皮性癌

Abstract: Ubiquitin modification is termed as an important way for the post-translational regulation of cellular protein, which is found involved in a serial of biological process, such as cell cycle, DNA repair signaling transduction, transcriptional regulation, and so on. Recently, ubiquitin modifications occurred in the malignant tumors have been observed and studied broadly. The specificity of ubiquitin modification rely on the E3 ubiquitin ligases for its specific action with certain substrates, dysfunction of which is shown to be related to the pathological processes of many diseases, including malignant tumors. The further analysis for the function of E3 ubiquitin ligases will strengthen our knowledge on the molecular mechanisms of carcinogenesis and development of malignant tumors, which might also provide biological targets for molecular classification and clinical treatment. Now a review was conducted for the function of one E3 ubiquitin ligase, carboxy terminus of Hsc70 interacting protein (CHIP), especially for its relationship with epithelial cancers.

Key words: E3 ubiquitin ligase, carboxy terminus of Hsc70 interacting protein (CHIP), epithelial cancer

中图分类号: 

• R739.8