长链非编码RNA MALAT1在头颈肿瘤中的研究进展

doi:10.3969/j.issn.1005-4979.2017.01.011

《口腔颌面外科杂志》 ›› 2017, Vol. 27 ›› Issue (1): 51-. doi: 10.3969/j.issn.1005-4979.2017.01.011

长链非编码RNA MALAT1在头颈肿瘤中的研究进展

刘慢慢，邵晓琳（综述）张韬（审校）

中国医学科学院北京协和医学院，北京协和医院口腔科，北京 100730

出版日期:2017-02-28 发布日期:2017-09-07
通讯作者: 张韬，教授 E-mail:drtzhang@126.com
作者简介:刘慢慢（1990—），山东东营人，住院医师，硕士研究生.
基金资助:
国家自然科学基金（81250043）

Research Progress of Long non-coding RNA MALAT1 in head and neck cancer

LIU Man-man, SHAO Xiao-lin, ZHANG Tao

Department of Stomatology, Peking Union Medical College Hospital, Chinase Academy of Medical Science and Pelcing Union Medical College, Beijing 100730, China

Online:2017-02-28 Published:2017-09-07

摘要/Abstract

摘要： 长链非编码RNA肺腺癌转移相关转录本1(MALAT1)被发现在肿瘤发生发展中具有重要作用。本文结合国内外最新研究报道，阐述了MALAT1的结构与功能及其在头颈肿瘤中的表达和可能的作用机制。MALAT1与多种头颈肿瘤的发生发展密切相关，有望成为头颈肿瘤早期诊断及靶向治疗的新途径。

关键词: 长链非编码RNA, 肺腺癌转移相关转录本1, 头颈肿瘤

Abstract: It has been found that metastasis-associated lung adenocarcinoma transcript 1（MALAT1）, one of long non-coding RNA（lncRNA）, plays an important role in the development of tumor. This article reviewed the structure and function of MALAT1, as well as the expression and mechanism in head and neck cancer. MALAT1 may serve as a new method for early diagnosis and target therapy of head and neck cancer.

Key words: lncRNA, MALAT1, head and neck cancer

中图分类号:

R782
R739.8

刘慢慢，邵晓琳（综述）张韬（审校）. 长链非编码RNA MALAT1在头颈肿瘤中的研究进展[J]. 《口腔颌面外科杂志》, 2017, 27(1): 51-.

LIU Man-man, SHAO Xiao-lin, ZHANG Tao. Research Progress of Long non-coding RNA MALAT1 in head and neck cancer[J]. 《Journal of Oral and Maxillofacial Surgery》, 2017, 27(1): 51-.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2017/V27/I1/51

参考文献

[1] Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2):115-132.

[2] Tachezy R, Klozar J, Rubenstein L, et al. Demographic and risk factors in patients with head and neck tumors[J]. J Med Virol, 2009, 81(5):878-887.

[3] Gupta RA, Shah N, Wang KC, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J]. Nature, 2010, 464(7291):1071-1076.

[4] Tano K, Mizuno R, Okada T, et al. MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes[J]. FEBS Lett, 2010, 584(22):4575-4580.

[5] Wilusz JE, Jnbaptiste CK, Lu LY, et al. A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails[J]. Genes Dev, 2012, 26(21):2392-2407.

[6] anko ML, Müller-Mcnicoll M, Brandl H, et al. The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes[J]. Genome Biol,2012, 13(3):1-17.

[7] Yang L, Lin C, Liu, Wet al. ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs[J]. Cell, 2011, 147(4):773-788.

[8] Jiang Y-G, Luo Y, He D-l, et al. Role of Wnt/β-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1α[J]. Int J Urol 2007, 14(11):1034-1039.

[9] Ji P, Diederichs S,Wang W, et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer[J]. Oncogene, 2003, 22(39):8031-8041.

[10] Sano D, Myers JN. Metastasis of squamous cell carcinoma of the oral tongue[J]. Cancer Metastasis Rev 200,26(3-4): 645-662.

[11] Gibb EA, Enfield KS, Stewart GL, et al. Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions[J]. Oral Oncol, 2011, 47(11):1055-1061.

[12] Tang H, Wu Z, Zhang J, et al. Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis[J]. Mol Med Rep, 2013, 7(3):761-766.

[13] Zhou X, Liu S, Cai G, et al. Long non coding RNA MALAT1 promotes tumor growth and metastasis by inducing epithelial-mesenchymal transition in oral squamous cell carcinoma[J]. Sci Rep, 2015, 5:15972.

[14] Micalizzi DS, Farabaugh SM, Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression[J]. J Mammary Gland Biol Neoplasia, 2010, 15(2):117-134.

[15] Fang Z, Wu L, Wang L, et al. Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2014, 117(1):89-95.

[16] 张珊珊, 杨宏宇, 王宇帆, 等. 长链非编码RNA MALAT1在舌鳞状细胞癌中的表达及生物学意义[J]. 中国口腔颌面外科杂志, 2015, 13(5):405-409.

[17] Liang J, Liang L, Ouyang K, et al. MALAT1 induces tongue cancer cells' EMT and inhibits apoptosis through Wnt/beta-catenin signaling pathway[J]. J Oral Pathol Med, 2016. doi: 10.1111/jop.12466.

[18] 谢林英, 胡志燕, 王晓燕, 等. 长非编码MALAT1基因在人鼻咽癌细胞株的表达及生物学意义[J]. 南方医科大学学报, 2013, 33(5):692-697.

[19] Jin C, Yan B, Lu Q, et al. The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma[J]. Tumour Biol, 2016, 37(3):4025-4033.

[20] Baumann M, Krause M, Hill R. Exploring the role of cancer stem cells in radioresistance[J]. Nat Rev Cancer, 2008, 8(7):545-554.

[21] Rudolph E, Dyckhoff G, Becher H, et al. Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis[J]. Eur Arch Otorhinolaryngol, 2011, 268(2):165-179.

[22] Feng J, Tian L, Sun Y, et al. Expression of long non-coding ribonucleic acid metastasis-associated lung adenocarcinoma transcript-1 is correlated with progress and apoptosis of laryngeal squamous cell carcinoma[J]. Head & Neck Oncology, 2012, 4(2):1-7.

[23] Chen H, Xin Y, Zhou L, et al. Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma[J]. Med Oncol, 2014, 31(11):1-13.

[24] Jemal A, Bray F, Center MM, et al. Global cancer statistics[J]. CA Cancer J Clin, 2011, 61(2):69-90.

[25] Hu L, Wu Y, Tan D, et al. Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma[J]. J Exp Clin Cancer Res, 2015, 34(1):1-13.

[26] Wang X, Li M, Wang Z, et al. Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells[J]. J Biol Chem, 2014, 290(7):3925-3935.

选择文件类型/文献管理软件名称

选择包含的内容

长链非编码RNA MALAT1在头颈肿瘤中的研究进展

Research Progress of Long non-coding RNA MALAT1 in head and neck cancer

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 10

编辑推荐

Metrics

本文评价

[1]	陈栋怡, 苏俭生. LincRNA-EPS对牙周炎小鼠肠道菌群影响的实验研究[J]. 《口腔颌面外科杂志》, 2023, 33(3): 138-147.
[2]	喻莉, 杨静, 宋泰来. 静态牵张力对人炎症牙周膜干细胞增殖及成骨分化的影响及分子机制探究[J]. 《口腔颌面外科杂志》, 2022, 32(4): 217-224.
[3]	郝晨笛，苏俭生. 长链非编码RNA-EPS对小鼠牙釉质发育的影响[J]. 《口腔颌面外科杂志》, 2021, 31(5): 272-.
[4]	胡安妮，苏俭生. LncRNA参与固有免疫及其在牙周炎症反应中的研究进展[J]. 《口腔颌面外科杂志》, 2021, 31(1): 52-55.
[5]	叶远舟，刘凯,王雅冰,苏俭生. LincRNA-EPS对脂多糖诱导的小鼠牙周膜细胞炎症因子表达的影响[J]. 《口腔颌面外科杂志》, 2021, 31(1): 1-8.
[6]	汪鑫苏俭生. 长链非编码RNA在口腔鳞状细胞癌中作用的研究进展[J]. 《口腔颌面外科杂志》, 2020, 30(5): 324-327.
[7]	张陈平. 口腔颌面头颈肿瘤诊治的挑战[J]. 《口腔颌面外科杂志》, 2020, 30(1): 1-.
[8]	蔡洁明，杨伟明，胡璇，舒传继. 长链非编码RNA HOTAIR在口腔鳞癌组织中的表达及临床意义[J]. 《口腔颌面外科杂志》, 2018, 28(2): 71-.
[9]	陈婵，石欢（综述）郑凌艳（审校）. 长链非编码RNA及其在自身免疫性疾病发生发展中的作用[J]. 《口腔颌面外科杂志》, 2016, 26(2): 140-144.
[10]	韩煦，徐晓刚. 长链非编码RNA的新认识及与头颈部肿瘤发生的关系[J]. 《口腔颌面外科杂志》, 2015, 25(1): 77-.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

长链非编码RNA MALAT1在头颈肿瘤中的研究进展

Research Progress of Long non-coding RNA MALAT1 in head and neck cancer

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 10

编辑推荐

Metrics

本文评价