TREM-2/DAP12复合物在牙周炎中的作用及研究进展

doi:10.3969/j.issn.1005-4979.2021.02.009

摘要/Abstract

摘要：

DNA X激活蛋白12（DNAX activation protein of 12 kDa，DAP12）是包含基于免疫受体酪氨酸激活基序（immune receptor tyrosine activated motif， ITAM）的I型跨膜衔接蛋白的成员。DAP12与髓样细胞触发受体2（trigger receptor expressed in myeloid cell 2，TREM-2）表达的触发受体形成分子复合物。牙周炎是口腔常见的一种慢性感染性疾病,牙周炎发生发展中，骨破坏和骨形成的调控信号通路会发生异常变化，而TREM-2/DAP12复合物在破骨细胞的生成和分化中起着重要的作用。本文总结了近年来TREM-2/DAP12复合物在牙周炎中作用的研究进展，以期为牙周炎的治疗提供新思路。

关键词: 牙周炎, TREM-2/DAP12复合物, 破骨细胞, 骨免疫学

Abstract:

DAP12（DNA X activation protein of 12 kDa） is a member of a type I transmembrane cohesive protein containing an immune receptor tyrosine activated motif (ITAM). DAP12 forms a molecular complex with the trigger receptor expressed in myeloid cell 2 (TREM-2). Periodontitis is a chronic infectious disease in oral cavity. During the development of periodontitis, abnormal changes will occur in the regulatory signaling pathways of bone destruction and bone formation, and the TREM-2/DAP12 complex plays an important role in the generation and differentiation of osteoclasts. This paper summarized the research progress of TREM-2/DAP12 complex in periodontitis in recent years, hoping to provide new ideas for the treatment of periodontitis.

Key words: periodontitis, TREM-2/DAP12 complex, osteoclast, osteoimmunology

中图分类号:

R782

李琴, 王佐林. TREM-2/DAP12复合物在牙周炎中的作用及研究进展[J]. 《口腔颌面外科杂志》, 2021, 31(2): 110-113.

LI Qin, WANG Zuolin. Recent advances of the role of TREM-2/DAP12 complex in pathogenesis of periodontitis[J]. 《Journal of Oral and Maxillofacial Surgery》, 2021, 31(2): 110-113.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2021/V31/I2/110

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