多孔仿生纳米材料作为蛋白缓释制剂的研究进展

doi:10.3969/j.issn.1005-4979.2021.03.011

《口腔颌面外科杂志》 ›› 2021, Vol. 31 ›› Issue (3): 185-188. doi: 10.3969/j.issn.1005-4979.2021.03.011

多孔仿生纳米材料作为蛋白缓释制剂的研究进展

雷婧诗（综述）(), 王佐林（审校）()

上海牙组织修复与再生工程技术研究中心，同济大学口腔医学院，同济大学附属口腔医院口腔种植科，上海 200072

收稿日期:2020-04-28 修回日期:2020-05-27 出版日期:2021-06-28 发布日期:2021-07-08
通讯作者: 王佐林，教授. E-mail: zuolin@tongji.edu.cn
作者简介:
雷婧诗（1991—），女，江西人，博士研究生. E-mail: leijingshi10@163.com
基金资助:
国家自然科学基金(81670962); 科技部重点研发专项(15042430003); 同济大学中央高校基本业务费专项资金(22120180196)

Recent advances of porous biomimetic nanoparticles as protein slow-release materials

LEI Jingshi(), WANG Zuolin()

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Oral Implantology, School and Hospital of Stomatology, Tongji University, Shanghai 200072, China

Received:2020-04-28 Revised:2020-05-27 Online:2021-06-28 Published:2021-07-08

摘要/Abstract

摘要：

蛋白质是生物系统的组成部分，蛋白质药物为现代医学疾病治疗提供了新的思路。然而，由于蛋白质三级结构脆弱，使得蛋白制剂的临床应用面临诸多困难。制备蛋白缓释制剂是保护蛋白质活性的有效方式。二氧化硅、磷酸钙和碳酸钙是常见的仿生纳米材料，因出色的理化特性、形貌可调性、生物相容性和降解速率等特点，其在蛋白缓释制剂中得到广泛研究。本文主要对二氧化硅、磷酸钙和碳酸钙3种多孔仿生纳米材料的理化性质、生物学特点及其在生物蛋白缓释领域的研究现状进行简要介绍。

关键词: 介孔二氧化硅, 磷酸钙, 碳酸钙, 纳米材料, 仿生

Abstract:

Proteins are important components of biological system, and provide a new way for treatment of diseases. However, due to the fragile tertiary structures, the clinical application of proteins faces many difficulties. Protein slow-release materials are effective ways to protect the activity of proteins. Due to the excellent physical and chemical properties, shape adjustability, biocompatibility and degradation rate, silica, calcium carbonate, and calcium phosphate have received significant attention. This review mainly introduces the physical and chemical properties and biological characteristics of three porous biomimetic nanomaterials of silica, calcium phosphate and calcium carbonate and their research status in the field of biological protein slow-release.

Key words: mesoporous silica, calcium phosphate, calcium carbonate, nanomaterials, biomimetic

中图分类号:

R782

雷婧诗, 王佐林. 多孔仿生纳米材料作为蛋白缓释制剂的研究进展[J]. 《口腔颌面外科杂志》, 2021, 31(3): 185-188.

LEI Jingshi, WANG Zuolin. Recent advances of porous biomimetic nanoparticles as protein slow-release materials[J]. 《Journal of Oral and Maxillofacial Surgery》, 2021, 31(3): 185-188.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2021/V31/I3/185

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