<p class="MsoNormal">
	<span>骨膜干细胞的研究进展及应用前景</span>

doi:10.12439/kqhm.1005-4979.2025.03.010

摘要/Abstract

摘要：

骨膜是覆盖在骨表面的具有良好骨再生能力的结缔组织，是用于骨修复的主要干细胞来源。本文综述了骨膜的组织结构及生理功能，并重点讨论了骨膜干细胞（periosteal stem cells，PSCs）的细胞标志物与生物学特征。近年来，单细胞测序等技术的应用不仅实现了不同骨膜细胞亚群的鉴定，更揭示了它们良好的增殖能力和多向分化潜能。研究表明，PSCs 在行使生物学功能时受到复杂的分子信号调控，且不同信号之间可能存在相互作用，共同协调其成骨潜能。本文进一步总结了 PSCs 在骨组织工程中的应用前景，并展望未来研究方向：一方面需深入解析 PSCs 的异质性；另一方面需探索不同 PSCs 亚群在组织工程及临床中的应用。

关键词:

骨膜, 干细胞, 骨再生, 骨组织工程

Abstract:

The periosteum, a connective tissue layer covering bone surfaces, possesses excellent bone regeneration capabilities and serves as the primary reservoir of stem cells for bone repair. This review summarizes the organizational structure and physiological functions of the periosteum, with a focus on the cell markers and biological characteristics of periosteal stem cells (PSCs). In recent years, utilizing techniques such as single-cell sequencing, different subsets have been identified, and their good proliferation and multilineage differentiation potential have been revealed. The biological functions of PSCs are regulated by complex molecular signals. There may be interactions between different signals to orchestrate periosteal stem cell activities. Additionally, this review outlines the prospective applications of PSCs in bone tissue engineering. Future investigations should prioritize exploring the heterogeneity of PSCs and exploring the application of different PSCs subsets in both tissue engineering and clinical settings.

Key words:

periosteum, stem cells, bone regeneration, bone tissue engineering

中图分类号:

R782

易祖木, 邓晨, 满毅.

骨膜干细胞的研究进展及应用前景[J]. 《口腔颌面外科杂志》, 2025, 35(3): 227-232.

YI Zumu, DENG Chen, MAN Yi.

Periosteal stem cells: Research progress and application prospect[J]. 《Journal of Oral and Maxillofacial Surgery》, 2025, 35(3): 227-232.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2025/V35/I3/227

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