颞下颌关节中成体间充质干细胞的研究进展

doi:10.12439/kqhm.1005-4979.2025.02.010

《口腔颌面外科杂志》 ›› 2025, Vol. 35 ›› Issue (2): 145-148. doi: 10.12439/kqhm.1005-4979.2025.02.010

颞下颌关节中成体间充质干细胞的研究进展

龚吴仪(), 米晓晖, 李永明()

上海市同济口腔医院正畸科，同济大学口腔医学院，上海牙组织修复与再生工程技术研究中心，同济大学口腔医学研究所，上海　200072

收稿日期:2023-03-30 接受日期:2023-10-05 出版日期:2025-04-28 上线日期:2025-04-28
通讯作者: 李永明
作者简介:
龚吴仪，博士研究生. E-mail:m18817870471@163.com
基金资助:
国家自然科学基金(81970921)

Research progress on the adult mesenchymal stem cells in the temporomandibular joint

GONG Wuyi(), MI Xiaohui, LI Yongming()

Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Orthodontics, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, China

Received:2023-03-30 Accepted:2023-10-05 Published:2025-04-28 Online:2025-04-28
Contact: LI Yongming

摘要/Abstract

摘要：

颞下颌关节（temporomandibular joint，TMJ）是下颌骨各项生理运动的结构基础，但其自我修复能力较差，病理状态导致的软骨与骨缺损难以再生。成体间充质干细胞（mesenchymal stem cells，MSCs）凭借其成软骨与成骨多向分化能力成为TMJ组织再生修复的研究热点。本文将聚焦TMJ中存在的成体MSCs，并对其近年的研究进展进行综述。

关键词: 颞下颌关节, 成体间充质干细胞, 祖细胞

Abstract:

The temporomandibular joint (TMJ) is the structural basis of mandibular movements, but its poor self-repairing ability makes the cartilage and bone defects hard to regenerate under pathological conditions. Adult mesenchymal stem cells（MSCs）have become a research hotspot in the tissue repairing of the TMJ due to their ability to differentiate toward chondrocytes and osteocytes. This article will focus on adult MSCs in the TMJ and review their recent research progress.

Key words: temporomandibular joint, adult mesenchymal stem cells, progenitor cells

中图分类号:

R782

龚吴仪, 米晓晖, 李永明. 颞下颌关节中成体间充质干细胞的研究进展[J]. 《口腔颌面外科杂志》, 2025, 35(2): 145-148.

GONG Wuyi, MI Xiaohui, LI Yongming. Research progress on the adult mesenchymal stem cells in the temporomandibular joint[J]. 《Journal of Oral and Maxillofacial Surgery》, 2025, 35(2): 145-148.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2025/V35/I2/145

参考文献 29

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