Abstract:

Bone is a metabolically active organ that undergoes continuous bone remodeling throughout life to maintain bone homeostasis. Amino acids are the basic units of proteins, which play an important role in the regulation of material metabolism and information transfer, and amino acid metabolism is closely related to bone remodeling and the development of osteoporosis. Therefore, elucidating their linkages is not only essential for a full understanding of bone biology, but also helps to clarify the pathogenesis of osteoporosis and explore new therapeutic targets. In this paper, the research progress on the role of amino acid metabolism in bone remodeling and osteoporosis is reviewed.

Key words: energy metabolism, bone remodeling, amino acid metabolism, osteocytes, osteoblasts, osteoclasts, osteoporosis

摘要：

骨骼是一个代谢活跃的器官，在整个生命过程需经历不断的骨重塑来维持骨稳态。氨基酸是组成蛋白质的基本单位，在物质代谢调控和信息传递中发挥重要作用，并且氨基酸代谢与骨重塑和骨质疏松症的发生密切相关。因此阐明二者之间的联系不仅对充分理解骨生物学具有重要意义，同时也为揭示骨质疏松症的发病机制和探寻新的治疗靶点提供了重要线索。本文就氨基酸代谢在骨重塑和骨质疏松症中作用的最新研究进展作一综述。

关键词: 能量代谢, 骨重塑, 氨基酸代谢, 骨细胞, 成骨细胞, 破骨细胞, 骨质疏松症

CLC Number: 

• R782