腺样囊性癌恶性表型与SNAI和EMT相关性的研究进展

doi:10.3969/j.issn.1005-4979.2016.03.014

《口腔颌面外科杂志》 ›› 2016, Vol. 26 ›› Issue (3): 222-226. doi: 10.3969/j.issn.1005-4979.2016.03.014

腺样囊性癌恶性表型与SNAI和EMT相关性的研究进展

刘通(综述) 费伟(审校)

1. 四川医科大学口腔医学院，四川泸州 646000；
2. 四川省医学科学院·四川省人民医院口腔科，四川成都 610072

收稿日期:2015-06-05 修回日期:2015-12-17 出版日期:2016-06-28 发布日期:2016-08-08
通讯作者: 费伟，教授. E-mail:fwross10@sina.com
作者简介:刘通（1988—），男，吉林人，硕士研究生. E-mail：liutong.520@163.com
基金资助:
四川省卫生厅科研基金项目(130185)

Recent Advances on the Correlations between SNAI Transcription Factors and Epithelial-mesenchymal Transition in Adenoid Cystic Carcinoma

LIU Tong，FEI Wei

1. School of Stomatology, Sichuan Medical University，Luzhou 646000, Sichuan Province;
2. Department of Stomatology, Sichuan Provincial People’s Hospital, Sichuan Provincial
Academy of Medical Sciences， Chengdu 610072, Sichuan Province, China

Received:2015-06-05 Revised:2015-12-17 Online:2016-06-28 Published:2016-08-08

摘要/Abstract

摘要： 腺样囊性癌虽早期病程缓慢，但具有明显侵袭性生长、远处转移、治疗抵抗等临床表现，预后较差。近期研究发现上皮间充质转化及以SNAI基因为核心的众多因子参与腺样囊性癌的侵袭转移过程，为我们深入了解腺样囊性癌的转移和侵袭机制打开了新的思路。

关键词: 腺样囊性癌, , , SNAI转录因子, , , 上皮细胞-间充质细胞转换

Abstract: Human adenoid cystic carcinoma (ACC) is characterize by diffuse invasion of the tumor into adjacent organs and early distant metastasis. Anoikis resistance and epithelial mesenchymal transition (EMT), are considered pre-requisites for cancer cells to metastasis. Recent studies have found that the most important function of SNAI gene was induction of EMT. Exploring the relationship between these process and their underlying mechanism of action is a promising way to a better understand of ACC.

Key words: adenoid cystic carcinoma, SNAI transcription factor, epithelial-mesenchymal transition

中图分类号:

R782
R739.87

刘通(综述) 费伟(审校). 腺样囊性癌恶性表型与SNAI和EMT相关性的研究进展[J]. 《口腔颌面外科杂志》, 2016, 26(3): 222-226.

LIU Tong，FEI Wei. Recent Advances on the Correlations between SNAI Transcription Factors and Epithelial-mesenchymal Transition in Adenoid Cystic Carcinoma[J]. 《Journal of Oral and Maxillofacial Surgery》, 2016, 26(3): 222-226.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2016/V26/I3/222

参考文献

[1] Lee MY, ShenMR. Epithelial-mesenchymal transition in cervical carcinoma[J].Am J Transl Res, 2012, 4(1):1-13.

[2] Wirtz D, Konstantopoulos K, SearsonPC. The physics of cancer: the role of physical interactions and mechanical forces in metastasis[J].Nat Rev Cancer, 2011, 11(7):512-522.

[3] 葛明华, 凌志强, 谭卓, 等. 涎腺腺样囊性癌组织中E-钙黏蛋白的表达及临床意义[J]. 中华医学杂志, 2012, 92(2):106-109.

[4] Zhong K, Chen W, Xiao N,et al.The clinicopathological significance and potential drug target of E-cadherin in NSCLC[J]. Tumour Biol, 2015, 36(8):6139-6148.

[5] ChallaAA, Stefanovic B. A novel role of vimentin filaments: binding and stabilization of collagen mRNAs[J].Mol Cell Biol, 2011, 31(18):3773-3789.

[6] Chang B, Li S, He Q, et al.Deregulation of Bmi-1 is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma[J].Biochim Biophys Acta, 2014, 1840(12):3285-3291.

[7] Lahat G, Zhu QS, Huang KL, et al.Vimentin is a novel anti-cancertherapeutic target; insights from in vitro and in vivo mice xenograftstudies[J].PLoS One, 2010, 5(4):e10105.

[8] Lim S, Becker A, Zimmer A, et al. SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance[J].PLoS One, 2013, 8(6):e66558.

[9] Wang Y, Shi J, Chai K, et al.The role of snail in EMT and tumorigenesis[J]. Curr Cancer Drug Targets, 2013, 13(9):963-972.

[10] Zheng H, Li W, Wang Y, et al.Glycogen synthase kinase-3 beta regulates Snail and β-catenin expression during Fas-induced epithelial-mesenchymal transition in gastrointestinal cancer[J].Eur J Cancer, 2013, 49(12):2734-2746.

[11] Lv Z, Hu M, Zhen J, et al.Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering β-catenin transcriptional activity under high glucose conditions[J].Int J Biochem Cell Biol, 2013, 45(2):255-264.

[12] Hogstrand C, Kille P, Ackland ML,et al. A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3)[J].Biochem J, 2013, 455(2):229-237.

[13] Jiang J, Tang Y, Zhu G, et al.Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland[J].Oral Surg Oral Med Oral Pathol Oral RadiolEndod, 2010, 110(6):764-769.

[14] Larriba MJ, Bonilla F, Munoz A. The transcription factorsSnail1 and Snail2 repress vitamin D receptor during colon cancer progression[J].J Steroid Biochem Mol Biol, 2010, 121(1-2):106-109.

[15] Martinez-Alonso M, Dusso A, Ariza G, et al.The effect on quality of life of vitamin D administration for advanced cancer treatment (VIDAFACT study): protocol of a randomised controlled trial[J]. BMJ Open, 2014, 4(12):e006128.

[16] Kajdaniuk D, Marek B, Borgiel-Marek H, et al.Transforming growth factor β1 (TGFβ1) in physiology and pathology[J].Endokrynol Pol, 2013, 64(5):384-396.

[17] Zu X, Zhang Q, Cao R, et al.Transforming growth factor-β signaling in tumor initiation, progression and therapy in breast cancer: an update[J].Cell Tissue Res, 2012, 347(1):73-84.

[18] Dong L, Ge XY, Wang YX, et al.Transforming growth factor-β and epithelial-mesenchymal transition are associated with pulmonary metastasis in adenoid cystic carcinoma[J].Oral Oncol, 2013, 49(11):1051-1058.

[19] Polakis P. Wnt signaling in cancer[J].Cold Spring Harb Perspect Biol, 2012, 4(5): 1-10.

[20] Vékony H, Ylstra B, Wilting SM, et al.DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma[J].Clin Cancer Res, 2007, 13(11):3133-3139.

[21] Yip WK, Seow HF.Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and β-catenin and enhances invasion in nasopharyngeal carcinoma cells [J].Cancer Lett, 2012, 318(2):162-172.

[22] Schonrath K, Klein-Szanto AJ, Braunewell KH.The putative tumor suppressor VILIP-1 counteracts epidermal growth factor-induced epidermal-mesenchymal transition in squamous carcinoma cells[J]. PLoS One, 2012, 7(3):e33116.

[23] Huang Y, Yu T, Fu X, et al.EGFR inhibition prevents in vitro tumor growth of salivary adenoid cystic carcinoma[J]. BMC Cell Biol, 2013, 14:13.

[24] Siu A, Lee C, Pham E, et al.Revisiting epithelial-to-mesenchymal transition through adenoid cystic carcinoma[J]. Anticancer Res, 2012, 32(9):3683-3688.

[25] Liang F, Zhang S, Wang B, et al. Overexpression of integrin-linked kinase (ILK) promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-κB pathway[J]. J MolHistol, 2014, 45(2):141-151.

[26] Zhu J, Pan X, Zhang Z, et al. Downregulation of integrin-linked kinase inhibits epithelial-to-mesenchymal transition and metastasis in bladder cancer cells[J]. Cell Signal, 2012, 24(6):1323-1332.

[27] Zhao D, Yang K, Tang XF, et al. Expression of integrin-linked kinase in adenoid cystic carcinoma of salivary glands correlates with epithelial-mesenchymal transition markers and tumor progression[J].Med Oncol, 2013, 30(3):619.

[28] Sussman D, Smith LM, Anderson ME, et al. SGN-LIV1A: a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer[J].Mol Cancer Ther, 2014, 13(12):2991-3000.

[29] Wu C, Li D, Jia W, et al. Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma[J].Nat Genet, 2013, 45(6):632-638.

[30] Shimoda M, Sugiura T, Imajyo I, et al. The T-box transcription factor Brachyury regulates epithelial-mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells[J]. BMC Cancer, 2012, 12:377.

[31] Tanaka K, Toiyama Y, Okugawa Y, et al. In vivo optical imaging of cancer metastasis using multiphoton microscopy: a short review[J].Am J Transl Res, 2014, 6(3):179-187.

选择文件类型/文献管理软件名称

选择包含的内容

腺样囊性癌恶性表型与SNAI和EMT相关性的研究进展

Recent Advances on the Correlations between SNAI Transcription Factors and Epithelial-mesenchymal Transition in Adenoid Cystic Carcinoma

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	胡永, 赵大勇, 叶金海, 江宏兵. 上唇腺样囊性癌1例及文献复习[J]. 《口腔颌面外科杂志》, 2022, 32(2): 132-134.
[2]	张雨菡，韩雯斐，孟博，苏俭生，肖凡. 调控小鼠腮腺分泌中枢神经系统相关核团的分布[J]. 《口腔颌面外科杂志》, 2019, 29(3): 121-.
[3]	马旭辉，王丽珍，任国欣，吴云腾，顾挺，郭伟. SOX10作为原发性口腔黏膜恶性黑色素瘤分子诊断指标的初步研究[J]. 《口腔颌面外科杂志》, 2019, 29(3): 131-.
[4]	范德生，甄蕾，汪黎明. miRNA-31对糖尿病小鼠来源骨髓间充质干细胞体外成骨分化的影响[J]. 《口腔颌面外科杂志》, 2019, 29(3): 137-.
[5]	郭泽鸿，周磊，徐淑兰，丁祥龙，赵春萍, 卢灿. 改良式骨劈开术水平骨增量对软硬组织的影响[J]. 《口腔颌面外科杂志》, 2019, 29(3): 142-.
[6]	张庆福，牛璐，符国才，聂恒金，吕春堂. 中段桥接式钛合金全下颌骨植入体的设计制作研究[J]. 《口腔颌面外科杂志》, 2019, 29(3): 148-.
[7]	吴东，林兆楠，林彦君，周麟，游冬冬，黄文秀，陈永辉. 自体牙来源骨移植材料在口腔种植中应用的短期临床观察[J]. 《口腔颌面外科杂志》, 2019, 29(3): 152-.
[8]	冯海楠，王淼，常晓峰，杜良智，周慧霞，李晓红，刘少丽，贺龙龙. 上颌窦底提升术后种植修复的十年临床回顾分析[J]. 《口腔颌面外科杂志》, 2019, 29(3): 159-.
[9]	施雄，李生娇，周剑萍，张利，李百龙. 锥形束CT在牙内陷诊断中的应用[J]. 《口腔颌面外科杂志》, 2019, 29(3): 164-.
[10]	岳广娜，王佐林. 石墨烯家族生物相容性的研究进展[J]. 《口腔颌面外科杂志》, 2019, 29(3): 169-.
[11]	孙睿男，王佐林. 单细胞转录组测序技术进展及其在间充质干细胞研究中的应用#br#[J]. 《口腔颌面外科杂志》, 2019, 29(3): 174-.
[12]	李宏权1，宋扬1，李志耀1，吴玉波1，钱文昊1，周曾同2. 丹酚酸B及其磷脂复合纳米粒抑制口腔鳞癌和白斑细胞株的作用[J]. 《口腔颌面外科杂志》, 2018, 28(6): 314-321.
[13]	王佐林，王方. 创新发展，求同存异 ——“争鸣与共识”种植论坛（第四季）学术共识[J]. 《口腔颌面外科杂志》, 2018, 28(2): 61-.
[14]	万会璇，蔡明详，孙瑶. 局部激活破骨细胞对大鼠应用双膦酸盐后拔牙创愈合的影响[J]. 《口腔颌面外科杂志》, 2018, 28(2): 65-.
[15]	李威，杨旭东，王志勇，卢晓林，王洋，王育新. 数字化技术辅助颌骨截骨及颌面修复的临床应用[J]. 《口腔颌面外科杂志》, 2018, 28(2): 75-.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

腺样囊性癌恶性表型与SNAI和EMT相关性的研究进展

Recent Advances on the Correlations between SNAI Transcription Factors and Epithelial-mesenchymal Transition in Adenoid Cystic Carcinoma

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价