下颌截骨术对兔颌骨非术区骨改建的影响

doi:10.3969/j.issn.1005-4979.2016.02.002

《口腔颌面外科杂志》 ›› 2016, Vol. 26 ›› Issue (2): 83-87. doi: 10.3969/j.issn.1005-4979.2016.02.002

下颌截骨术对兔颌骨非术区骨改建的影响

黄丹青，康非吾，周小康，吴情，纪映辰，王伟伟，马嘉磊

同济大学口腔医学院·同济大学附属口腔医院口腔颌面外科，上海牙组织修复与再生工程技术研究中心，上海 200072

收稿日期:2015-11-04 修回日期:2016-01-31 出版日期:2016-04-28 发布日期:2016-06-07
通讯作者: 康非吾，教授. E-mail:kangfeiwu@126.com
作者简介:黄丹青（1989—），女，江苏泰州人，住院医师，硕士.

Mechanism of Action and Morphologic Changes in the Mandible
in Response to Surgery-First Approach: a Rabbit Model

Dan-qing, KANG Fei-wu, ZHOU Xiao-kang, WU Qing,JI Ying-chen, WANG Wei-wei, MA Jia-lei

Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072,China

Received:2015-11-04 Revised:2016-01-31 Online:2016-04-28 Published:2016-06-07

摘要/Abstract

摘要： 目的：研究正颌手术对非手术区骨组织改建的影响，以更好地了解正颌手术加速颌骨改建的机制。方法：12只新西兰大白兔随机分成4组，每组3只，9只行“双下颌骨磨牙区矢状截骨术”为手术组，3只为对照组。手术组9只按处死时间点分为术后1周组、3周组和8周组。每只动物单侧下颌骨用于Micro?鄄CT扫描，对侧下颌骨用于组织学观察。结果：术后下颌骨整个骨组织发生吸收，在术后3周骨丧失最为显著，在术后8周骨形态恢复到近似对照组。下颌骨前牙区（非手术区）在术后1周至3周骨吸收较对照组活跃，表现为骨皮质内血管增生，出现破骨细胞和骨吸收陷窝，在术后3周达到高峰；在术后8周骨组织则与对照组无异。结论：正颌手术后，颌骨先是骨吸收活跃伴破骨细胞增多，骨改建加速，随后新骨生成，骨组织恢复。

关键词: 骨改建, , , 截骨术, , , 破骨细胞, , , 局部骨加速现象

Abstract: Objective: To study the impact of mandibular osteotomy on bone remodeling. Methods: 12 rabbits were randomly and equally divided into 4 groups . Animals in 3 experiment groups were treated by bilateral mandibular osteotomy, the last group was control. The rabbits in experiment groups were sacrificed on 1-week, 3-week, and 8-week respectively. 3 mandible bone of each group were used for Micro-CT scanning, the other 3 mandible bones were used for histological examination. Results: The bone density of the whole mandible had reduced obviously on 3-week, in addition with a higher count of osteoclasts appeared in alveolar bone of incisor region. On 8-week, bone morphology recovered and showed similarity with the control group. Conclusion: Mechanism of regional acceleratory phenomenon may be related to enhancement of osteoclast differentiation and reduction of bone density.

Key words: bone remodeling, osteotomy, osteoclast, regional acceleratory phenomenon

中图分类号:

R782.13

黄丹青，康非吾，周小康，吴情，纪映辰，王伟伟，马嘉磊. 下颌截骨术对兔颌骨非术区骨改建的影响[J]. 《口腔颌面外科杂志》, 2016, 26(2): 83-87.

HUANG Dan-qing, KANG Fei-wu, ZHOU Xiao-kang, WU Qing,JI Ying-chen, WANG Wei-wei, MA Jia-lei. Mechanism of Action and Morphologic Changes in the Mandible
in Response to Surgery-First Approach: a Rabbit Model[J]. 《Journal of Oral and Maxillofacial Surgery》, 2016, 26(2): 83-87.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2016/V26/I2/83

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Mechanism of Action and Morphologic Changes in the Mandible
in Response to Surgery-First Approach: a Rabbit Model