长链非编码RNA在口腔鳞状细胞癌中作用的研究进展

doi:10.3969/j.issn.1005-4979.2020.05.012

《口腔颌面外科杂志》 ›› 2020, Vol. 30 ›› Issue (5): 324-327. doi: 10.3969/j.issn.1005-4979.2020.05.012

长链非编码RNA在口腔鳞状细胞癌中作用的研究进展

汪鑫(), 苏俭生()

上海牙组织修复与再生工程技术研究中心，同济大学口腔医学院，同济大学附属口腔医院修复科，口腔修复教研室，上海 200072

收稿日期:2019-12-03 修回日期:2020-05-29 出版日期:2020-10-28 发布日期:2020-10-27
通讯作者: 苏俭生，教授. E-mail: sjs@tongji.edu.cn
作者简介:
汪鑫（1995—），女，黑龙江人，硕士研究生. E-mail: 1833249@tongji.edu.cn
基金资助:
国家自然科学基金(81873715)

Research Progress on the Role of Long Non-coding RNA in Oral Squamous Cell Carcinoma

WANG Xin(), SU Jiansheng()

Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Prosthodontics, School and Hospital of Stomatology, Tongji University, Shanghai 200072, China

Received:2019-12-03 Revised:2020-05-29 Online:2020-10-28 Published:2020-10-27

摘要/Abstract

摘要：

长链非编码RNA(long non-coding RNA, lncRNA)是一类长度>200 nt的非蛋白质编码转录物。近年来的研究表明，lncRNA在基因组调控、转录及转录后的过程中均发挥重要作用，其差异表达被认为是控制物种进化、胚胎发育、代谢和疾病发展中基因表达及表观遗传调控的重要因素之一。本文就lncRNA在口腔鳞状细胞癌（oral squamous cell carcinoma, OSCC）中功能作用的研究进展进行总结，为口腔癌症类疾病的治疗及预后评估提供新的应用策略。

关键词: 长链非编码RNA, 口腔鳞状细胞癌, 舌鳞状细胞癌

Abstract:

Long non-coding RNA(LncRNA) is a kind of nonprotein encoded transcript with greater than 200 nucleotides.Recent studies have shown that they play an important role in genome regulation, transcription and post transcription. Differential expression of lncRNA is recognized as one of the important factors controlling gene expression and epigenetic regulation in the evolution of species, embryonic development, metabolism, and disease development. In this paper, the functional role of lncRNA in oral squamous cell carcinoma (OSCC) is summarized, which may provide a new application strategy for the treatment and prognosis evaluation of oral cancer.

Key words: long non-coding RNA (lncRNA), oral squamous cell carcinoma (OSCC), tongue squamous cell carcinoma (TSCC)

中图分类号:

R782
R739.8

汪鑫, 苏俭生. 长链非编码RNA在口腔鳞状细胞癌中作用的研究进展[J]. 《口腔颌面外科杂志》, 2020, 30(5): 324-327.

WANG Xin, SU Jiansheng. Research Progress on the Role of Long Non-coding RNA in Oral Squamous Cell Carcinoma[J]. 《Journal of Oral and Maxillofacial Surgery》, 2020, 30(5): 324-327.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2020/V30/I5/324

参考文献 25

[1]	屈茜, 房付春, 吴补领. 长链非编码RNA在牙周炎和口腔肿瘤疾病中的作用[J]. 国际口腔医学杂志, 2016, 43(1): 62-65.
[2]	Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease[J]. Cell Mol Life Sci, 2016, 73(13): 2491-2509. doi: 10.1007/s00018-016-2174-5 pmid: 27007508
[3]	Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional suprises from the RNA world[J]. Genes Dev, 2009, 23(13): 1494-1504. doi: 10.1101/gad.1800909 URL
[4]	Arunkumar G, Deva Magendhra Rao AK, Manikandan M, et al. Expression profiling of long non-coding RNA identifies linc-RoR as a prognostic biomarker in oral cancer[J]. Tumour Biol, 2017, 39(4): 1010428317698366.
[5]	Gomes CC, de Sousa SF, Calin GA, et al. The emerging role of long noncoding RNAs in oral cancer[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2017, 123(2): 235-241. doi: 10.1016/j.oooo.2016.10.006 URL
[6]	Fatima R, Akhade VS, Pal D, et al. Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets[J]. Mol Cell Ther, 2015, 3: 5. doi: 10.1186/s40591-015-0042-6 URL
[7]	Fang ZY, Wu LM, Wang L, et al. Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2014, 117(1): 89-95. doi: 10.1016/j.oooo.2013.09.007 URL
[8]	Fang Z, Zhao JF, Xie WH, et al. LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression[J]. Cancer Med, 2017, 6(12): 2897-2908. doi: 10.1002/cam4.2017.6.issue-12 URL
[9]	Yang YT, Wang YF, Lai JY, et al. Long non-coding RNA UCA1 contributes to the progression of oral squamous cell carcinoma by regulating the Wnt/β-catenin signaling pathway[J]. Cancer Sci, 2016, 107(11): 1581-1589. doi: 10.1111/cas.2016.107.issue-11 URL
[10]	Li SM, Chen XJ, Liu XQ, et al. Complex integrated analysis of lncRNAs-miRNAs-mRNAs in oral squamous cell carcinoma[J]. Oral Oncol, 2017, 73: 1-9. doi: S1368-8375(17)30217-8 pmid: 28939059
[11]	Zhang TH, Liang LZ, Liu XL, et al. Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1[J]. Oncol Rep, 2017, 37(4): 2087-2094. doi: 10.3892/or.2017.5445 URL
[12]	Fang ZY, Zhang SS, Wang YF, et al. Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins[J]. BMC Cancer, 2016, 16: 706. doi: 10.1186/s12885-016-2735-x pmid: 27586393
[13]	Wang PJ, Ren ZQ, Sun PY. Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation[J]. J Cell Biochem, 2012, 113(6): 1868-1874. doi: 10.1002/jcb.24055 pmid: 22234798
[14]	Gao W, Chan JY, Wong TS. Long non-coding RNA deregulation in tongue squamous cell carcinoma[J]. Biomed Res Int, 2014, 2014: 405860.
[15]	Zhang LL, Hu D, Zou LH. Low expression of lncRNA MEG3 promotes the progression of oral squamous cell carcinoma by targeting miR-21[J]. Eur Rev Med Pharmacol Sci, 2018, 22(23): 8315-8323.
[16]	Tan JW, Xiang LX, Xu GC. LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR-548d-3p to modulate JAK-STAT pathway in oral squamous cell carcinoma[J]. IUBMB Life, 2019, 71(7): 882-890. doi: 10.1002/iub.2012 pmid: 30809930
[17]	Ye ZY, Zhou M, Tian B, et al. Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance[J]. Int J Clin Exp Med, 2015, 8(3): 3707-3715. pmid: 26064266
[18]	王玉佩, 冷卫东, 牛玉明, 等. OSCC组织特征性lncRNA表达谱及lncRNA CCAT2在口腔鳞状细胞癌发生、发展中的作用[J]. 临床和实验医学杂志, 2018, 17(19): 2089-2092.
[19]	Gibb EA, Brown CJ, Lam WL. The functional role of long non-coding RNA in human carcinomas[J]. Mol Cancer, 2011, 10: 38. doi: 10.1186/1476-4598-10-38 pmid: 21489289
[20]	Lu MY, Liao YW, Chen PY, et al. Targeting LncRNA HOTAIR suppresses cancer stemness and metastasis in oral carcinomas stem cells through modulation of EMT[J]. Oncotarget, 2017, 8(58): 98542-98552. doi: 10.18632/oncotarget.v8i58 URL
[21]	González-Ramírez I, Irigoyen-Camacho ME, Ramírez-Amador V, et al. Association between age and high-risk human Papilloma virus in Mexican oral cancer patients[J]. Oral Dis, 2013, 19(8): 796-804. doi: 10.1111/odi.12071 pmid: 23379359
[22]	Momen-Heravi F, Bala. Emerging role of non-coding RNA in oral cancer[J]. Cell Signal, 2018, 42: 134-143. doi: S0898-6568(17)30277-2 pmid: 29056500
[23]	Zhang CZ. Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression[J]. Gene, 2017, 607: 47-55. doi: 10.1016/j.gene.2017.01.009 URL
[24]	Liang S, Zhang SZ, Wang P, et al. LncRNA, TUG1 regulates the oral squamous cell carcinoma progression possibly via interacting with Wnt/β-catenin signaling[J]. Gene, 2017, 608: 49-57. doi: S0378-1119(17)30046-X pmid: 28119088
[25]	Kong XP, Yao J, Luo W, et al. The expression and functional role of a FOXC1 related mRNA-lncRNA pair in oral squamous cell carcinoma[J]. Mol Cell Biochem, 2014, 394(1-2): 177-186. doi: 10.1007/s11010-014-2093-4 URL

选择文件类型/文献管理软件名称

选择包含的内容

长链非编码RNA在口腔鳞状细胞癌中作用的研究进展

Research Progress on the Role of Long Non-coding RNA in Oral Squamous Cell Carcinoma

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献 25

相关文章 15

编辑推荐

Metrics

本文评价

[1]	楚晨, 薛雨, 闫周, 邱建平, 储伟明. cT1N0M0口腔鳞状细胞癌浸润深度对预测淋巴结转移和评价预后的影响[J]. 《口腔颌面外科杂志》, 2024, 34(1): 40-44.
[2]	王静璇, 刘红悦, 庄志征, 胡燕, 杨英顺. MMP-9抑制剂对人口腔鳞状细胞癌细胞系CAL27生物学行为影响机制的研究[J]. 《口腔颌面外科杂志》, 2023, 33(6): 363-369.
[3]	张瑾, 程政, 闫小静, 雷冰. 口腔鳞状细胞癌患者根治性切除术后感染的风险预测模型构建与验证[J]. 《口腔颌面外科杂志》, 2023, 33(6): 385-390.
[4]	周新谊, 叶涛, 邱凤美. miR-503靶向作用RECK调控口腔鳞状细胞癌细胞增殖、侵袭和凋亡的机制研究[J]. 《口腔颌面外科杂志》, 2023, 33(5): 305-313.
[5]	姜胜军, 陈燕, 金中直, 黄思博. LncRNA CDKN2BAS在口腔鳞状细胞癌组织中的表达及对细胞增殖和侵袭的影响[J]. 《口腔颌面外科杂志》, 2023, 33(4): 224-228.
[6]	陈栋怡, 苏俭生. LincRNA-EPS对牙周炎小鼠肠道菌群影响的实验研究[J]. 《口腔颌面外科杂志》, 2023, 33(3): 138-147.
[7]	王晓玲, 强金彪, 曲明, 张雨晴, 乔春燕, 张泽兵, 史册. HPV相关性和非HPV相关性口腔/口咽鳞状细胞癌的临床病理分析[J]. 《口腔颌面外科杂志》, 2023, 33(3): 155-163.
[8]	陈燕, 姜胜军. miR-378a在口腔鳞状细胞癌中的表达及意义[J]. 《口腔颌面外科杂志》, 2023, 33(2): 95-98.
[9]	贾国栋, 汪轶, 徐震. PTK7在口腔鳞状细胞癌中的表达及临床意义[J]. 《口腔颌面外科杂志》, 2023, 33(2): 99-103.
[10]	侯泽宇, 唐金茹, 李龙江. 口腔鳞状细胞癌发生、发展过程中细胞周期调控因子的研究进展[J]. 《口腔颌面外科杂志》, 2023, 33(2): 119-122.
[11]	齐延旭, 马川, 朱勇, 黄晟栋, 赵华强, 张风河. 基于自噬相关基因建立和验证口腔鳞状细胞癌的预后风险评分模型[J]. 《口腔颌面外科杂志》, 2022, 32(6): 343-353.
[12]	张璧茹, 陈羽菱, 沈月洪, 杨宏宇. 牙龈肉瘤样(梭形细胞)癌1例并文献复习[J]. 《口腔颌面外科杂志》, 2022, 32(6): 383-385.
[13]	周陶, 丁小容, 李九群, 杨宏宇, 方丹, 李梅, 王毅芬. 口腔鳞状细胞癌术后并发肺部感染的风险预测模型建立及护理策略[J]. 《口腔颌面外科杂志》, 2022, 32(5): 297-302.
[14]	喻莉, 杨静, 宋泰来. 静态牵张力对人炎症牙周膜干细胞增殖及成骨分化的影响及分子机制探究[J]. 《口腔颌面外科杂志》, 2022, 32(4): 217-224.
[15]	曹顺顺, 汪晓龙, 舒传继, 邵剑杰, 李红霞. 黏蛋白4在口腔鳞状细胞癌组织中的表达及意义[J]. 《口腔颌面外科杂志》, 2022, 32(4): 231-235.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

长链非编码RNA在口腔鳞状细胞癌中作用的研究进展

Research Progress on the Role of Long Non-coding RNA in Oral Squamous Cell Carcinoma

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献 25

相关文章 15

编辑推荐

Metrics

本文评价