口腔鳞状细胞癌发生、发展过程中细胞周期调控因子的研究进展

doi:10.3969/j.issn.1005-4979.2023.02.011

《口腔颌面外科杂志》 ›› 2023, Vol. 33 ›› Issue (2): 119-122. doi: 10.3969/j.issn.1005-4979.2023.02.011

口腔鳞状细胞癌发生、发展过程中细胞周期调控因子的研究进展

侯泽宇(), 唐金茹, 李龙江()

口腔疾病研究国家重点实验室，国家口腔疾病临床医学研究中心，四川大学华西口腔医院头颈肿瘤外科，四川成都 610041

修回日期:2023-03-07 接受日期:2022-12-25 出版日期:2023-04-28 发布日期:2023-05-05
通讯作者: 李龙江，教授. E-mail：muzili63@163.com
作者简介:
侯泽宇，硕士研究生. E-mail：3448103821@qq.com
基金资助:
国家自然科学基金(82141130)

Research progress on cell cycle regulation-related molecules in the development of oral squamous cell carcinoma

HOU Zeyu(), TANG Jinru, LI Longjiang()

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China

Revised:2023-03-07 Accepted:2022-12-25 Online:2023-04-28 Published:2023-05-05

摘要/Abstract

摘要：

口腔鳞状细胞癌（oral squamous cell carcinoma, OSCC）是口腔颌面部最常见的恶性肿瘤。对细胞周期调控因子调控机制的深入研究表明，其以多种方式参与OSCC的发生、发展。本文分析总结了近年来OSCC中细胞周期调控因子的研究成果及OSCC发生、发展中相关分子的作用特点，以期为OSCC的早期诊断和靶向治疗寻找潜在的生物标志物，为提高患者生存率提供新的思路。

关键词: 口腔鳞状细胞癌, 细胞周期蛋白, 细胞周期蛋白依赖性激酶, 细胞周期蛋白依赖性激酶抑制剂

Abstract:

Oral squamous cell carcinoma (OSCC) is the most common oral and maxillofacial cancer. In-depth research on the regulatory mechanism of cell cycle regulation-related molecules has revealed that these molecules play various roles in the incidence and progression of OSCC. This paper analyzes the recent research progress of cell cycle regulation-related molecules in OSCC, as well as the functional characteristics of related molecules in the development of OSCC, to find potential biomarkers for the early diagnosis and targeted therapy of OSCC, and to improve patient survival rate.

Key words: oral squamous cell carcinoma, cyclin, cyclin dependent kinases, cyclin dependent kinase inhibitor

中图分类号:

R782

侯泽宇, 唐金茹, 李龙江. 口腔鳞状细胞癌发生、发展过程中细胞周期调控因子的研究进展[J]. 《口腔颌面外科杂志》, 2023, 33(2): 119-122.

HOU Zeyu, TANG Jinru, LI Longjiang. Research progress on cell cycle regulation-related molecules in the development of oral squamous cell carcinoma[J]. 《Journal of Oral and Maxillofacial Surgery》, 2023, 33(2): 119-122.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2023/V33/I2/119

参考文献 23

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口腔鳞状细胞癌发生、发展过程中细胞周期调控因子的研究进展

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