仿生结构理念在骨组织工程支架构建中的应用

doi:10.12439/kqhm.1005-4979.2025.02.009

《口腔颌面外科杂志》 ›› 2025, Vol. 35 ›› Issue (2): 142-144. doi: 10.12439/kqhm.1005-4979.2025.02.009

仿生结构理念在骨组织工程支架构建中的应用

王云(), 王佐林()

上海市同济口腔医院口腔种植科，同济大学口腔医学院，上海牙组织修复与再生工程技术研究中心，同济大学口腔医学研究所，上海　200072

收稿日期:2023-11-30 接受日期:2024-01-22 出版日期:2025-04-28 上线日期:2025-04-28
通讯作者: 王佐林，教授. E-mail:zuolin@tongji.edu.cn
作者简介:
王云，博士研究生. E-mail:2010747@tongji.edu.cn
基金资助:
国家重点研发计划(2018YFE0202202); 国家重点研发计划(2018YFE0202200)

Application of biomimetic structural concept in bone tissue engineering scaffolds

WANG Yun(), WANG Zuolin()

Shanghai Engineering Research Center of Tooth Restoration and Regeneration & Tongji Research Institute of Stomatology & Department of Oral Implantology, Shanghai Tongji Stomatological Hospital and Dental School, Tongji University, Shanghai 200072, China

Received:2023-11-30 Accepted:2024-01-22 Published:2025-04-28 Online:2025-04-28

摘要/Abstract

摘要：

骨组织工程（bone tissue engineering，BTE）支架的成分、孔径、孔隙率、机械性能等对骨再生的影响已被广泛研究。然而，目前关于其多尺度结构设计影响骨再生的研究仍不充分。基于仿生技术的发展，通过模仿天然材料的多尺度结构来改善BTE支架的机械性能和生物学活性以促进骨再生，是一种有前景的策略。因此，本文综述了近年来仿生结构材料在BTE支架中的研究进展，并讨论了未来发展的机遇和挑战，旨在为设计出性能更优越的BTE支架提供灵感。

关键词: 骨组织工程, 骨组织工程支架, 骨再生, 仿生结构材料

Abstract:

The influence of component composition, pore size, porosity, and mechanical properties of bone tissue engineering (BTE) scaffolds on bone regeneration has been extensively studied. However, there is currently a lack of research on the impact of multi-scale structural design on bone regeneration. With the advancement of biomimetic technology, mimicking the multi-scale structures of natural materials presents a promising strategy to enhance the mechanical performance and biological activity of BTE scaffolds and facilitate bone regeneration. As such, this review provides a summary of recent advances in biomimetic structural materials utilized in BTE scaffolds, discussing future development opportunities and challenges with the aim of inspiring the design of BTE scaffolds with superior properties.

Key words: bone tissue engineering, bone tissue engineering scaffolds, bone regeneration, biomimetic structural materials

中图分类号:

R782

王云, 王佐林. 仿生结构理念在骨组织工程支架构建中的应用[J]. 《口腔颌面外科杂志》, 2025, 35(2): 142-144.

WANG Yun, WANG Zuolin. Application of biomimetic structural concept in bone tissue engineering scaffolds[J]. 《Journal of Oral and Maxillofacial Surgery》, 2025, 35(2): 142-144.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2025/V35/I2/142

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