《口腔颌面外科杂志》 ›› 2024, Vol. 34 ›› Issue (4): 310-313. doi: 10.12439/kqhm.1005-4979.2024.04.010

• 综述 • 上一篇    下一篇

甘草酸在骨关节炎治疗中的研究进展

胡智慧1,3,4(), 龙星1,2()   

  1. 1 口颌系统重建与再生全国重点实验室,口腔生物医学教育部重点实验室,口腔医学湖北省重点实验室,武汉大学口腔医(学)院,武汉 430079
    2 武汉大学口腔医院口腔颌面创伤与颞下颌关节外科,武汉 430079
    3 天津市口腔医院咬合及颞下颌关节病科,南开大学医学院,天津 300041
    4 天津市口腔功能重建重点实验室,天津 300041
  • 收稿日期:2023-07-05 接受日期:2023-10-16 出版日期:2024-08-28 发布日期:2024-08-26
  • 通讯作者: 龙星,教授. E-mail:longxing@whu.edu.cn
  • 作者简介:
    胡智慧,医师. E-mail:
  • 基金资助:
    国家自然科学基金(82170983)

Research progress of glycyrrhizin in the treatment of osteoarthritis

HU Zhihui1,3,4(), LONG Xing1,2()   

  1. 1 State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine, Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079
    2 Department of Oral and Maxillofacial Trauma and Temporomandibular Joint Surgery, Hospital of Stomatology, Wuhan University, Wuhan 430079
    3 Department of Occlusion and Temporomandibular Joint Diseases, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041
    4 Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China
  • Received:2023-07-05 Accepted:2023-10-16 Online:2024-08-28 Published:2024-08-26

摘要:

甘草酸提取自甘草根,具有抗炎、抗氧化、抗肿瘤、抗病毒等多种作用。目前关于甘草酸在骨关节炎中的作用及机制研究较少。因此,本综述总结了甘草酸的分子生物学特点、药理作用和主要作用靶点,以及对骨关节炎(osteoarthritis,OA)中炎症和氧化应激调控作用的研究现状,探讨甘草酸在OA研究中的价值。

关键词: 甘草酸, 抗炎, 氧化应激, 骨关节炎

Abstract:

Glycyrrhizin is extracted from licorice root and has anti-inflammatory, antioxidant, anti-tumor, anti-viral and other effects. At present, there are few studies on the role and mechanism of glycyrrhizin in osteoarthritis. This review summarizes the molecular biological characteristics, pharmacological functions and main targets of glycyrrhizin, as well as the research status of its regulatory effects on inflammation and oxidative stress in osteoarthritis (OA), and discusses the value of glycyrrhizin in the research of OA.

Key words: glycyrrhizin, anti-inflammation, oxidative stress, osteoarthritis

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