长链非编码RNA及其在自身免疫性疾病发生发展中的作用

doi:10.3969/j.issn.1005-4979.2016.02.014

摘要/Abstract

摘要： 长链非编码RNA(long non-coding RNA, lncRNA)是一类长度超过200个核苷酸、不编码蛋白质的功能性RNA分子。lncRNA通过表观遗传修饰与转录调控、转录后加工、翻译调控等多种机制，在细胞生命活动中发挥重要作用。最新研究表明，lncRNA与免疫细胞的分化和激活密切相关，进而影响类风湿性关节炎、系统性红斑狼疮等多种自身免疫性疾病的发生发展，本文就lncRNA在自身免疫性疾病中的研究进展进行综述。

关键词: 长链非编码RNA, , , 自身免疫性疾病, , , 基因芯片技术

Abstract: Long non-coding RNA (lncRNAs) is a functional non-protein-coding class whose length is longer than 200 nucleotides. Recent studies have demonstrated that a series of patterns including epigenetic modification and protein modification，regulation of target gene expression，and transcription intervention are involved in this process. The lncRNAs play crucial role in differentiation and activation of immune cells, and its relationship with human autoimmune diseases has been given more and more attention. With the development of microarray, many of the potential function of lncRNA have been discovered gradually. This article reviews recent research advances in this aspect with an attempt to better understand the role of LncRNA in autoimmune diseases .

Key words: , long noncoding RNA, autoimmune disease, microarray

中图分类号:

R782

陈婵，石欢（综述）郑凌艳（审校）. 长链非编码RNA及其在自身免疫性疾病发生发展中的作用[J]. 《口腔颌面外科杂志》, 2016, 26(2): 140-144.

CHEN Chan, SHI Huan, ZHENG Ling-yan. Recent Advances on Long Noncoding RNA and the Autoimmune Diseases[J]. 《Journal of Oral and Maxillofacial Surgery》, 2016, 26(2): 140-144.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2016/V26/I2/140

参考文献

[1] Bonasio R, Shiekhattar R. Regulation of transcription by long noncoding RNAs[J]. Annu Rev Genet, 2014, 48:433-455．

[2] Jalali S, Kapoor S, Sivadas A, et al. Computational approaches towards understanding human long non-coding RNA biology[J]. Bioinformatics, 2015, 31(14):2241-2251.

[3] Wright MW, Bruford EA. Naming 'junk': human non-protein coding RNA (ncRNA) gene nomenclature[J]. Hum Genomics, 2011, 5(2):90-98.

[4] Esteller M. Non-coding RNAs in human disease[J]. Nat Rev Genet, 2011, 12(12): 861-874.

[5] Hung T, Chang HY. Long noncoding RNA in genome regulation: prospects and mechanisms[J]. RNA Biol, 2010, 7( 5):582-585.

[6] Li CH, Chen Y. Targeting long non-coding RNAs in cancers: progress and prospects[J]. Int J Biochem Cell Biol, 2013, 45(8):1895-1910.

[7] Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs[J]. Cell, 2009, 136(4) : 629-641.

[8] Mercer TR，Dinger ME，Mattick JS. Long non-coding RNAs: insights into functions[J]. Nat Rev Genet, 2009, 10 (3):155-159.

[9] Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world[J]. Genes Dev, 2009, 23(13): 1494-1504.

[10] Bhartiya D, Pal K, Ghosh S, et al. IncRNome: a comprehensive knowledgebase of human long noncoding RNAs[J]. Database(Oxford), 2013, 2013: bat034.

[11] Zhao J, Sun BK, Erwin JA, et al. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome[J]. Science, 2008, 322(5902):750-756.

[12] Heuston EF, Lemon KT, Arceci RJ. The beginning of the road for non-coding RNAs in normal hematopoiesis and hematologic malignancies[J]. Front Genet, 2011, 2: 94．

[13] Ma L, Bajic VB, Zhang Z. On the classification of long non-coding RNAs[J]. RNA Biol, 2013, 10(6):925-933．

[14] Derrien T, Johnson R, Bussotti G, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression[J]. Genome Res, 2012, 22(9):1775-1789．

[15] Ledford H. Circular RNAs throw genetics for a loop[J]. Nature, 2013, 494(7438):415.

[16] Mercer TR, Dagmar W, Dinger ME, et al. Expression of distinct RNAs from 3' untranslated regions[J]. Nucleic Acids Res, 2011, 39(6):2393-2403.

[17] Smemo S, Campos LC, Moskowitz IP, et al . Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease[J]. Hum Mol Genet, 2012, 21(14):3255-3263.

[18] Fang XY, Pan HF, Leng RX, et al. Long noncoding RNAs: novel insights into gastric cancer[J]. Cancer Lett, 2015, 356(2 Pt B):357-366.

[19] Schonrock N, Harvey RP, Mattick JS. Long noncoding RNAs in cardiac development and pathophysiology[J]. Circ Res, 2012, 111(10):1349-1362.

[20] Shi X, Sun M, Liu H, et al. Long non-coding RNAs: a new frontier in the study of human diseases[J]. Cancer Lett, 2013, 339(2):159-166.

[21] Gibb EA, Vucic EA, Enfield KS, et al. Human cancer long non-coding RNA transcriptomes. PloS One, 2011, 6(10):e25915.

[22] Faghihi MA, Modarresi F, Khalil AM, et al. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta -secretase[J]. Nat Med, 2008, 14(7):723-730.

[23] McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease[J]. Science, 2007, 316(5830):1488-1491.

[24] Li J, Xuan Z, Liu C. Long non-coding RNAs and complex human diseases[J]. Int J Mol Sci, 2013, 14( 9):18790-18808.

[25] 彭武建, 王红蕾, 欧阳昕, 等. 系统性红斑狼疮患者长链非编码RNA差异性表达研究[J].中国现代医学杂志,2012, 22(11): 42-47.

[26] Suarez-Gestal M, Calaza M, Endreffy E, et al. Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study[J]. Arthritis Res Ther, 2009, 11(3):R69.

[27] Kino T, Hurt DE, Ichijo T, et al. Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor[J]. Sci Signal, 2010, 3(107):ra8.

[28] Haywood ME, Rose SJ, Horswell S, et al. Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes[J]. Genes Immun, 2006, 7(3):250-263.

[29] Yamanaka H. TNF as a Target of Inflammation in Rheumatoid Arthritis[J]. Endocr Metab Immune Disord Drug Targets, 2015, 15(2):129-134.

[30] Harrison P, Pointon JJ, Chapman K, et al. Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis[J]. Rheumatology (Oxford), 2008, 47(12):1768-1770.

[31] Solus JF, Chung CP, Oeser A, et al. Genetics of serum concentration of IL-6 and TNFα in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis[J]. Clin Rheumatol, 2015, 34(8):1375-1382.

[32] Song J, Kim D, Han J, et al. PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis[J]. Clin Exp Med, 2015, 15(1):121-126.

[33] Stuhlmuller B, Kunisch E, Franz J, et al. Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue[J]. Am J Pathol, 2003, 163(3):901-911.

[34] Müller N, Düring F, Klapper M, et al. Interleukin-6 and tumour necrosis factor-α differentially regulate lincRNA transcripts in cells of the innate immune system in vivo inhuman subjects with rheumatoid arthritis[J]. Cytokine, 2014, 68(1):65-68.

[35] Sigdel KR, Cheng A, Wang Y, et al. The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases[J]. J Immunol Res, 2015, 2015:848790.

[36] Sonkoly E, Bata-Csorgo Z, Pivarcsi A, et al. Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS[J]. J Biol Chem, 2005, 280(25):24159-24167.

[37] Szegedi K, Sonkoly E, Nagy N, et al. The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS[J]. Exp Dermatol, 2010, 19(3):269-278.

[38] Holm SJ, Sánchez F, Carlén LM, et al. HLA-Cw*0602 associates more strongly to psoriasis in the Swedish population than variants of the novel 6p21.3 gene PSORS1C3[J]. Acta Derm Venereol, 2005, 85(1):2-8.

[39] Chang YT, Chou CT, Shiao YM, et al. Psoriasis vulgaris in Chinese individuals is associated with PSORS1C3 and CDSN genes[J]. Br J Dermatol, 2006, 155(4):663-669.

[40] Kalk WW, Mansour K, Vissink A, et al. Oral and ocular manifestations in Sjogren's syndrome[J]. J Rheumatol, 2002, 29(5):924-930.

[41] Fox RI. Sjogren's syndrome[J]. Lancet, 2005, 366(9482):321-331.

[42] Djebali S, Davis CA, Merkel A, et al. Landscape of transcription in human cells[J]. Nature, 2012, 489(7414) : 101-108．

[43] Banfai B, Jia H, Khatun J, et al. Long noncoding RNAs are rarely translated in two human cell lines[J]. Genome Res, 2012, 22(9):1646-1657．

选择文件类型/文献管理软件名称

选择包含的内容