LncRNA参与固有免疫及其在牙周炎症反应中的研究进展

doi:10.3969/j.issn.1005-4979.2021.01.010

《口腔颌面外科杂志》 ›› 2021, Vol. 31 ›› Issue (1): 52-55. doi: 10.3969/j.issn.1005-4979.2021.01.010

LncRNA参与固有免疫及其在牙周炎症反应中的研究进展

胡安妮(), 苏俭生()

上海牙组织修复与再生工程技术研究中心，同济大学口腔医学院，同济大学附属口腔医院口腔修复科，上海 200072

收稿日期:2020-03-20 修回日期:2020-12-25 出版日期:2021-02-28 发布日期:2021-02-25
通讯作者: 苏俭生，教授. E-mail: sjs@tongji.edu.cn
作者简介:
胡安妮（1994—），女，陕西宝鸡人，博士研究生. E-mail:annihu4653@outlook.com
基金资助:
国家自然科学基金项目(81873715); 国家自然科学基金项目(81572114); 上海市科学技术委员会项目(18441902100); 上海市科学技术委员会项目(201409006200)

Recent Advances of LncRNA in Innate Immunity and Its Role in Periodontitis Pathogenesis

HU Anni(), SU Jiansheng()

Shanghai Engineering Reasearch Center of Tooth Restoration and Regeneration, Department of Prosthodontics, School and Hospital of Stomatology, Tongji University, Shanghai 200072, China

Received:2020-03-20 Revised:2020-12-25 Online:2021-02-28 Published:2021-02-25

摘要/Abstract

摘要：

固有免疫应答的特点是在病原刺激下，细胞内信号快速级联，为机体提供抗感染的最初防御。长链非编码RNA（long noncoding RNA，lncRNA）作为非编码RNA领域中的新星，是固有免疫的重要调节剂，与炎性疾病的病程密切相关。牙周炎是造成成年人牙齿缺失的主要原因，涉及牙周组织对病原体的固有免疫应答和级联炎症反应，它的发生、发展也与lncRNA有关。现就lncRNA参与固有免疫的作用及其与牙周炎症反应关系的研究进展作一综述。

关键词: 长链非编码RNA, 固有免疫, 炎症, 炎症小体, 牙周炎

Abstract:

The innate immune response is characterized by the rapid cascades of intracellular signals under the stimulation of pathogens, providing an initial defense against infection. Long noncoding RNA(lncRNA) as a new star in the field of noncoding RNA, has been proved to be an important regulator of innate immunity, which closely related to the development of inflammatory diseases. Periodontitis is the main cause of tooth loss in adults. It involves the innate immune responses and cascade inflammatory responses of periodontal tissue to pathogens, which is also related to lncRNA. In this review, we will present an overview of the functional roles of lncRNA in innate immunity and its relationship with inflammatory responses within periodontitis.

Key words: long noncoding RNA, innate immunity, inflammation, inflammasome, periodontitis

中图分类号:

R782

胡安妮, 苏俭生. LncRNA参与固有免疫及其在牙周炎症反应中的研究进展[J]. 《口腔颌面外科杂志》, 2021, 31(1): 52-55.

HU Anni, SU Jiansheng. Recent Advances of LncRNA in Innate Immunity and Its Role in Periodontitis Pathogenesis[J]. 《Journal of Oral and Maxillofacial Surgery》, 2021, 31(1): 52-55.

https://journal06.magtech.org.cn/Jweb_joms/CN/Y2021/V31/I1/52

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