摘要： 目的：比较不同方法灌注5-FU后，犬舌及颌下淋巴结组织内的药物浓度。方法：16只健康家犬称重后随机分为A组（舌动脉给药）和B组（股静脉给药）。分别行经舌动脉及股静脉持续24 h灌注5-FU。在12、24 h采集2组灌注侧舌体组织及下颌下淋巴结。反相高效液相色谱法（RP-HPLC）检测以上采集组织标本中5-FU含量。结果：全麻状态下，犬能耐受24 h舌动脉持续灌注5-FU并保持生命体征平稳。舌动脉灌注组舌体组织及颌下淋巴结内5-FU浓度，明显高于股静脉给药组。结论：5-FU舌动脉持续灌注后，舌及下颌下淋巴结的药物浓度均明显高于股静脉持续灌注。

关键词: 舌动脉持续灌注；  , 股静脉持续灌注；  , 5-FU；舌体组织；  , 颌下淋巴结；  , 犬

Abstract: Objective: To study concentrations of 5-FU in tongue and submandibular lymph nodes by using different infusion methods. Methods： Sixteen dogs were divided randomly into two groups, Group A was used intra-lingual arterial drug infusion and Group B was femoral vein drug infusion. 5-FU was continuously infused to lingual artery by superficial temporal artery retrograde intubation and femoral vein by micro-infusion pump, respectively. The ipsilateral tongue and submandibular lymphatic nodes were harvested at 12 h, 24 h. The concentration of 5-FU in tissues at different time point were determined by PR-HPLC. Results： The dogs could withstand 24 h continuous 5-FU infusion through lingual artery under general anesthesia and maintain stable vital signs. The drug concentration in ipsilateral tongue and submandibular lymphatic nodes by intra-lingual arterial infusion was much higher than that of femoral vein infusion. Conclusion: 5FU concentrations in submandibular lymph nodes and tongue using continuous lingual artery infusion found to be much higher than that of femoral vein infusion.

Key words: continuous lingual artery infusion, continuous femoral vein infusion, 5-FU, tongue tissue, submandibular lymph nodes, dogs

中图分类号: 

• R739.81